The precise mechanisms whereby gastro-oesophageal reflux disease causes reflux oesophagitis and Barrett's oesophagus are not clear, even though these diseases have been known to be linked for many years. Recent studies indicate a role for the reflux-induced inflammatory response of oesophageal squamous epithelial cells and the immune cells in the pathogenesis of reflux oesophagitis. Although re...

Musculoskeletal tissues are constantly under mechanical strains within their microenvironment. Yet, little is understood about the effect of in vivo mechanical milieu strains on cell development and function. Thus, this review article outlines the in vivo mechanical environment of bone, muscle, cartilage, tendon, and ligaments, and tabulates the mechanical strain and stress in these tissues dur...

Abstract Central limit theorems for functionals of general state space Markov chains are of crucial importance in sensible implementation of Markov chain Monte Carlo algorithms as well as of vital theoretical interest. Different approaches to proving this type of results under diverse assumptions led to a large variety of CTL versions. However due to the recent development of the regeneration t...

ORC (Organic Rankine Cycle) has potential of reducing consumption of fossil fuels and has many favorable characteristics to exploit low-temperature heat sources. In this work thermodynamic performance of ORC with regeneration is comparatively assessed for various working fluids. Special attention is paid to the effects of system parameters such as the turbine inlet pressure on the characteristi...

Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply to the brain. Regeneration of neural cells is a critical process for repairing the damaged brain. Nogo has been identified as an inhibitor of neurite outgrowth that is specific to the brain. In the present study, the Nogo-A receptor (NgR) antagonist NEP1-40 was used to study the effects of inhibition of NgR o...

In vitro germplasms of ipecac (Cephaelis ipecacuanha Rich.), an important medicinal plant, maintained through reduced growth conditions for more than 12-years, were used as source material for micropropagation. MS with different combinations of Kn (2 mg/l), BAP (2 mg/l), 2iP (2-3 mg/l), NAA (0.2 mg/l) and adenine (40-100 mg/l) as additive was used to induce fresh multiplication of shoots from t...

Vision impairment caused by loss of retinal neurons affects millions of people worldwide, and currently, there is no effective treatment. Müller glia of mammalian retina may represent an under-recognized and potential source for regeneration of a wide range of retinal cell types, including retinal ganglion cells and photoreceptors. Here, we demonstrated that mouse Müller glia cells have the cap...

This paper presents a novel signal trajectory based noise compensation algorithm for robust speech recognition. Its performance is evaluated on the Aurora 2 database. The algorithm consists of two processing stages: 1) noise spectrum is estimated using trajectory autosegmentation and clustering, so that spectral subtraction can be performed to roughly estimate the clean speech trajectories; 2) ...

Abstract Background Lactones are important compounds in the field of medicine, material and chemical industry. One promising accesses to these flexible scaffolds is NAD(P) + -dependent alcohol dehydrogenases-catalyzed oxidative lactonization diols, which relies on construction an efficient regeneration system. Results In this study, a novel system combining horse liver dehydrogenase (HLADH) wit...