Megalencephalic leukoencephalopathy (MLC) is a rare neurological disorder with an autosomal recessive pattern. Clinical diagnosis was based on macrocephaly, recurrent seizure, and magnetic resonance imaging (MRI). Here we report first finding of a novel homozygous single base deletion in the MLC1 gene in an affected Iranian child causing a premature stop codon (p.L150fs.160X).

Kawasaki disease is very rare in Western Europe. The disease may involve coronary arteries. A 2-year-old boy diagnosed with Kawasaki disease had had seizure-like symptoms. Further evaluation revealed recurrent myocardial ischemia and myocardial infarction. Due to extraordinary extension of the coronary disease, myocardial revascularization was not feasible and the toddler underwent successful h...

Generalized seizures involve both brain hemispheres and can affect the whole body, associated with loss of consciousness. It is important to differentiate between seizures and epilepsy, which is recurrent seizures due to known or unknown factors. Two or more seizure episodes without return to baseline activity and mental status, or continuous five minutes of seizures, is known as status epilept...

Glenohumeral instability following seizures is usually of the posterior type. Rarely patients can have anterior dislocation of the shoulder following an epileptic seizure. Although these are treated similar to usual anterior dislocations of the shoulder they need regular follow up to detect any recurrent shoulder instability for which the treatment will involve skeletal reconstruction. We repor...

Patterns of seizure occurrence and recurrent risks in patients with newly diagnosed epilepsy. Abstracts of the 15th epzlepsv internaitonal 33 Juul-Jensen P. Frequency of recurrence after discontinuance of anticonvulsant therapy in patients with epileptic seizures. A new follow up study after 5 years.

Generalized seizures involve both brain hemispheres and can affect the whole body, associated with loss of consciousness. It is important to differentiate between seizures and epilepsy, which is recurrent seizures due to known or unknown factors. Two or more seizure episodes without return to baseline activity and mental status, or continuous five minutes of seizures, is known as status epilept...

quency of cortical malformations in childhood epilepsy. However, very little is knownregarding the pathophysiological mechanisms of epileptogenicity in the malformed cortex, partly because of the rarity of experimental studies with animal models. In rats, the application of methylazoxymethanol (MAM) in utero (E15) results in the formation of dysplastic regions in the neocortex and the CA1 regio...

Epileptic seizures are composed of recurrent bursts of intense firing separated by periods of electrical quiescence. The mechanisms responsible for sustaining seizures and generating recurrent bursts are yet unclear. Using whole cell voltage recordings combined with intracellular calcium fluorescence imaging from bicuculline (BCC)-treated neocortical brain slices, I showed isolated paroxysmal d...