SINCE this condition was first described (Butler, 1930), only a handful ofcases has been added to the literature. In view of its infrequency, some cases are presented and compared with previous descriptions. Perhaps the name, although anatomically descriptive, is unfortunate, for it would imply that the condition has some relationship with the better-known conical cornea. In fact, there is no e...

In keratoconus, the cornea becomes progressively ectactic resulting in severe visual impairment. Here, we use a combination of videokeratography and synchrotron X-ray diffraction to investigate the relationship between corneal shape and thickness, and the distribution and predominant orientation of stromal fibrillar collagen in five keratoconus corneas. In all but the least advanced case, the t...

PURPOSE To determine whether patients with sporadic, non-familial keratoconus and no pathogenic mutations in the visual system homeobox 1 (VSX1) gene have evidence of chromosomal copy number alterations. METHODS Twenty Saudi Arabian patients with isolated keratoconus, no family history of the disease and no mutations in VSX1 were recruited. Additionally, 10 ethnically-matched healthy controls...

To compare the efficacy of epithelium-off corneal collagen crosslinking (CXL) with transepithelial CXL in patients progressive keratoconus a follow-up 3 years, taking into account patients’ age and location ectasia. In this prospective study participated 64 eyes were included long-term study, which 31 treated by 33 CXL. All 36 months evaluated for visual variables (corrected distance acuity (CD...

Objectives: To find out the prevalence and severity of keratoconus in spring catarrh patients. Study Design: Descriptive Perspective study. Setting: OPD K.D.A Teaching Hospital Kohat. Period: March 2017 to October 2019. Material & Methods: All patients suffering from were included study after consent. Proper proforma was designed for record. Detail history taken diagnosis all properly exami...

Purpose: To compare and assess the ability of pressure-derived parameters and corneal deformation waveform signal-derived parameters of the ocular response analyzer (ORA) measurement to distinguish between keratoconus and normal eyes, and to develop a combined parameter to optimize the diagnosis of keratoconus. Materials and methods: One hundred and seventy-seven eyes (177 patients) with kerato...

PURPOSE To assess the long-range outcomes of photorefractive keratectomy (PRK) using functional and topographic criteria in myopic eyes with suspected keratoconus. SETTING Rothschild Foundation, Paris, France. DESIGN Retrospective interventional case series. METHODS Eyes of patients classified as keratoconus suspects or keratoconus by the Corneal Navigator software of the OPD-Scan II devi...

PURPOSE To investigate and map the polarizing properties of keratoconus corneas in vitro and to compare the results with those obtained in normal corneas. METHODS Corneal buttons of five keratoconus corneas were investigated by polarization-sensitive optical coherence tomography (PS-OCT). The instrument measures backscattered intensity (conventional OCT), retardation, and (cumulative) slow ax...

Keratoconus, a common inherited ocular disorder resulting in progressive corneal thinning, is the leading indication for corneal transplantation in the developed world. Genome-wide association studies have identified common SNPs 100 kb upstream of ZNF469 strongly associated with corneal thickness. Homozygous mutations in ZNF469 and PR domain-containing protein 5 (PRDM5) genes result in brittle ...

PURPOSE To determine pachymetric, aberrometric, and topometric indices in patients with definite and subclinical keratoconus and the validity of these indices in the diagnosis of keratoconus. METHODS We evaluated 262 keratoconic and 97 healthy eyes in this study. Pentacam HR examination was performed for all participants, and the data of all pachymetric, aberrometric, and topometric indices w...