Background: The aim of this study was to investigate the association between plasma levels of homocysteine and the occurrence and progression of rectal cancer. Material/Methods: The 320 study participants included healthy controls (n=80). and patients with rectal tumors (n=240), including 155 patients with rectal cancer, Stage I (n=32), Stage II (n=38), Stage III (n=50), and Stage IV (n=35), an...

background and objectives: the etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (srus) is poorly understood. aim: to examine the pathology of mucosal changes and clinical features of this syndrome. materials and methods: the mucosal biopsies of 19 patients with clinical evidence of solitary rectal ulcer as been reviewed in accordance with the...

background the sitting position, rather than squatting, during defecation has been hypothesized to be a risk factor for colorectal cancer (crc). methods we conducted a case-control study to test this hypothesis. a total of 100 crc cases from two hospitals in iran and 100 control subjects, selected from the coronary care unit (ccu) of those same hospitals were selected for this study. we adminis...

Background and aims: To elucidate the dynamics of nitric oxide (NO) production induced by rectal gluten challenge and the relation between NO production and mucosal granulocyte activation. Subjects and methods: Release of rectal NO was measured in 13 patients with coeliac disease and in 18 controls before and after rectal wheat gluten challenge. Rectal gas was collected with a rectal balloon us...

Disturbance of miRNA expression may play a key role in the initiation and progression of colorectal cancer (CRC). CRC should be viewed as a heterogeneous disease, but previous studies have only screened dysregulated miRNAs in CRC from a panel of 96, 145, 287 and 455 miRNAs, respectively. It is necessary to identify new aberrantly expressed miRNAs ...

one of the debates concerning concepts of “medial motion” and “traversal motion” is the question of which of these two concepts of motion corresponds to motion in the corporeal world. in the present article we intend to employ the language of mathematics to present a model for each of these two concepts to study the above mentioned problem. as a result, medial motion represents a covering funct...

Rectal cancers have more local relapses than colonic cancers. Since nuclear -catenin plays an important role for the proliferation capacity of cells, we wanted to evaluate whether there may be differences in the expression pattern of nuclear -catenin between rectal and colonic adenocarcinomas, explaining the observations made in clinical practice. Sections from 235 rectal adenocarcinomas treate...

BACKGROUND Surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. METHODS Patients referred to the British Columbia Cancer Agency for consideration of adjuvant therapy for rectal adenocarcinoma were included. Predictors of margin positivity were determined from uni- and multivariate analysis. RESULTS Among 340 patients, 83% had negative resect...