The diagnostic and therapeutic approach to respiratory disease in the immunocompromised host remains a challenge for several reasons: (1) the current increase in both the number of immunocompromised hosts and their length of survival; (2) the high frequency of lung disease in these patients, and (3) the severity of these lung diseases. A good example is given in a recent review by Paterson et a...

OBJECTIVES Heart and lung transplant recipients are at risk for invasive fungal infections. This study evaluated the affect of single-agent antifungal prophylaxis with itraconazole on the rate of fungal infections after heart or lung transplant. MATERIALS AND METHODS An observational, retrospective study was performed to evaluate the rate of fungal infections in heart and lung transplant reci...

1. Haemodynamics, blood volume, plasma renin concentration and creatinine clearance were evaluated in 24 stable renal transplant recipients. 2. The mean cardiac index of the transplant recipients was not different from that of the normal subjects. 3. The transplant recipients comprised eight hypertensive and 16 normotensive patients. The mean cardiac index was the same in eight hypertensive and...

A significantly higher survival rate was obtained when frozen-thawed morulae were transferred to oviducts of recipients ovulating after donors rather than to those of synchronized or earlier ovulating recipients. The highest proportion of live young, 23%, was obtained after transfer of eggs to recipients ovulating 18 h after donors. The proportion of live young (48%) was significantly increased...

Between June, 1984 and January 20, 1987, 69 kidney transplantations were performed in our department. All kidneys were acquired from living donors. 63% of the cases were high-risk MLC-positive (poorly matched), and all but one were from related sources. There were only five rejected kidneys, all of which occurred in kidneys from parent donors. 28 recipients received donor-specific transfus...

Aim/Background: With respect to the immunosuppressive treatment of older kidney graft recipients no unique recommendations are available or generally accepted. At our centre we developed a renal sparing regimen which combined the highly efficacious intra-operative single high-dose induction using ATG-Fresenius (9 mg/kg body weight) with a low cyclosporine trough level throughout the first post-...

BACKGROUND Two of the major risk factors for hepatitis C are injection drug use and receipt of blood or blood products. Many patients are unaware that they have received transfusions. In 1998 Prince Edward Island conducted a province-wide look-back notification program to notify patients who had received transfusions in PEI between Jan. 1, 1984, and June 1, 1990. The authors present the results...

The expression of checkpoint blockade molecules PD-1, PD-L1, CTLA-4, and foxp3+CD25+CD4+ T cells (Tregs) regulate donor T cell activation and graft-vs-host disease (GvHD) in allogeneic hematopoietic stem cell transplant (allo-HSCT). Detailed kinetics of PD-1-, CTLA-4-, and PD-L1 expression on donor and host cells in GvHD target organs have not been well studied. Using an established GvHD model ...

Background: Hepatitis C virus infection confers 1.62-2.39 fold increase in risk of death for hemodialysis patients. The quality of life, morbidity and mortality of chronic kidney disease patients on maintenance hemodialysis is worse when compared to the quality of life, morbidity and mortality of patients undergoing renal transplantation. For these reasons, renal transplantation is better thera...

The diagnostic and therapeutic approach to respiratory disease in the immunocompromised host remains a challenge for several reasons: (1) the current increase in both the number of immunocompromised hosts and their length of survival; (2) the high frequency of lung disease in these patients, and (3) the severity of these lung diseases. A good example is given in a recent review by Paterson et a...