objective: in an attempt to develop safer and more effective gene therapy approaches as a realistic treatment for various forms of cancer, researchers are increasingly using tumor-specific promoters (tsp) to drive the expression of the gene of interest and eradicate cancer cells. in this study, for the first time we introduce the oct-4 promoter as a cancer-specific promoter with a high efficacy...

Molecular dynamics simulations of membrane proteins have provided deeper insights into their functions and interactions with surrounding environments at the atomic level. However, compared to solvation of globular proteins, building a realistic protein/membrane complex is still challenging and requires considerable experience with simulation software. Membrane Builder in the CHARMM-GUI website ...

Four methods have been proposed that can be used to test for associations between the states of discrete characters in cross-species data and that do not suffer from non-independence due to overcounting of data points. The tests are those of Ridley (1983), Burt (1989), Grafen (1989), and a new test called the ICDE test. The aim of the paper is to measure the Type I error rates for these methods...

The availability of affordable and portable depth sensors has made scanning objects and people simpler than ever. However, dealing with occlusions and missing parts is still a significant challenge. The problem of reconstructing a (possibly non-rigidly moving) 3D object from a single or multiple partial scans has received increasing attention in recent years. In this work, we propose a novel le...

We report new results on blood flow modeling over large volumes of cortical gray matter of primate brain. We propose a network method for computing the blood flow, which handles realistic boundary conditions, complex vessel shapes, and complex nonlinear blood rheology. From a detailed comparison of the available models for the blood flow rheology and the phase separation effect, we are able to ...

The Relaxed Complex method will be used in many of the new experiments performed on the FightAIDS@Home grid. This wll allow us to evaluate potential drugs by docking fullyflexible versions of known and potential inhibitors against an ensemble of hundreds to thousands of different conformations of the target protein. In other words, we examine how well a potential drug binds to and blocks a mass...

In this paper, we demonstrate a system for synthesizing high-resolution, realistic 3D human body shapes according to user-specified anthropometric parameters. We begin with a corpus of whole-body 3D laser range scans of 250 different people. For each scan, we warp a common template mesh to fit each scanned shape, thereby creating a one-to-one vertex correspondence between each of the example bo...

An algorithm is described which simulates a data set obtained from a protein crystal using the rotation method. The diffraction pattern of an ideal crystal is specified by the orientation of the crystal's cell axes with respect to a specified laboratory coordinate system, the distance between the crystal and the detector, the wavelength and the rotation range per frame. However, a realistic sim...

In this paper, we present an efficient method to synthesize large-scale scenes, such as broad city landscapes. To date, model based approaches have mainly been adopted for this purpose, and some fairly convincing polygon cities have been successfully generated. However, the shapes of real world objects are usually very complicated and it is infeasible to model an entire city realistically. On t...

In this paper, we address the problem of curve and surface reconstruction from sets of points. We introduce regular interpolants, which are polygonal approximations of curves and surfaces satisfying a new regularity condition. This new condition, which is an extension of the popular notion of r-sampling to the practical case of discrete shapes, seems much more realistic than previously proposed...