BACKGROUND Mild cognitive impairment (MCI) is the intermediate stage of the cognitive changes between normal aging and dementia. KLOTH is an age-related gene that may contribute to the risk of MCI. The aim of our study was to explore the association between KLOTHO promoter methylation and MCI in Xinjiang Uygur and Han populations. METHODS DNA methylation assay was performed using the bisulphi...

OBJECTIVE Research has reported associations among selected genetic susceptibility biomarkers and risk of (a) normal cognitive aging decrements, (b) established mild cognitive impairment (MCI), and (c) sporadic Alzheimer's disease (AD). In focusing on the transitional normal-to-early MCI phase, we examine associations among three theoretically relevant polymorphisms (APOE [rs429358, rs7412], BD...

BACKGROUND Criteria for mild cognitive impairment (MCI) consider impairment in instrumental activities of daily living (IADL) as exclusionary, but cross-sectional studies suggest that some high-level functional deficits are present in MCI. This longitudinal study examines informant-rated IADL in MCI, compared with cognitively normal (CN) older individuals, and explores whether functional abilit...

Background: Mild Cognitive Impairment (MCI) is defined as significant memory impairment that lies somewhere on the spectrum between normal, healthy aging and dementia. Tests of verbal fluency are simple and efficient tools that have shown to be sensitive enough to discriminate between healthy aging and early cognitive decline. The purpose of this study was to investigate letter and category ver...

BACKGROUND Mild Cognitive Impairment (MCI) is a borderline state between age-associated cognitive decline and mild dementia. MCI is separated from mild dementia by an absence of global intellectual deterioration and the preservation of activities of daily living (ADL). However, even mild degrees of cognitive deterioration are known to have negative effects on complex ADL. OBJECTIVES To examin...

BACKGROUND Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored. OBJECTIVE To investigate the association between the MeDi and MCI. DESIGN, SETTING, AND PATIENTS In a multiethnic community study in New York, we used Cox proportional hazards to investigate the association betw...

BACKGROUND/AIMS Greater cognitive and functional deficits in mild cognitive impairment (MCI) are associated with higher rates of dementia. We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices. METHODS We analyzed data from 1,108 MCI ...

Subjective cognitive complaints (SCC) are currently considered to be a core feature of mild cognitive impairment (MCI). Yet the implications of including or excluding subjective complaints has not been previously considered. The key questions are how many healthy people complain of SCC compared to those with MCI? How is the epidemiology of MCI affected by the requirement for SCC? How is the pro...

OBJECTIVE To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI). PATIENTS A follow-up examination (average follow-up period: 3.49 +/- 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline. RESULTS 8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 ...

Mild cognitive impairment (MCI) is a concept that was introduced by Flicker et al 1 and the Mayo Clinic group 2,3 to fill the gap between cognitive changes associated with normal aging and those associated with dementia. The concept of MCI draws attention to cognitive disturbances that occur before the clinical diagnosis of demen-tia. The cognitive changes, measured by neuropsycho-logical test ...