hsa-miR-195-5p (miR-195) has been proven to be a critical regulator in the progression of prostate cancer (PCa). To identify additional targets and molecular functions of miR-195, we overexpressed miR-195 by transient oligonucleotide transfection in DU145 and LNCaP cells and examined the effects. RNA-based microarray and dual-luciferase assays were carried out to identify novel targets of miR-1...

Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocy...

BACKGROUND Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations. OBJECTIVE The objective was to evaluate the effect of a moderate intake of red wine polyphenols on select gut microbial groups implicated in host health benefits. DESIGN Ten healthy male volun...

Purpose. Analysis of the avifauna on territory water treatment facilities to assess their importance in support and conservation birds at Kharkiv region. Methods. Field survey: records permanent routes. Statistical analysis. Results. Avifauna (hereinafter WTF) region 2019 - 2023 amounted 195 species from 17 orders 44 families. Passeriformes dominated (37.7%; n=159), Charadriiformes (16.6%) Anse...

BACKGROUND Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). However, the relationship between BDNF and microRNA (miRNA) in cardiomyocytes are unclear. The present study was performed to investigate the role of miR-195 and the interplay between BDNF and miR-195 in...

In this paper, a modified sol-gel method using peroxotitanic acid sol (PTA) was applied for the preparation of TiO2 nanostructured thin films on glass plates. The peroxotitanic acid sol was synthesized using titanium isopropoxide, isopropylalchol, H2O and hydrogen peroxide. TiO2 films were then calcined at 500oC and characterized by X-ray diffraction ...

Introduction: Dyes are visible materials and are considered as one of the hazardous components that make up industrial waste. Therefore it is removed from bodies of water, using various methods. In this regard, the Fenton oxidation process is one of the most effective ways to remove colored contaminants in aquatic environments, which has many applications today. Materials and Methods: In this...

We investigated the effects of fermented red beet extract and ascorbic acid on color development in meat emulsions. The pH of meat emulsions containing red beet extract decreased with an increase in the amount of extract added. The redness of the treated meat emulsions was higher than that of the control with no added nitrite or fermented red beet extract (p<0.05), though the redness of the mea...

MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial-mesenchymal transition (EMT) and the progression of hepatocellular carcinoma (HCC) as well as the underlying mechanisms. Our result demonstrated that miR-195 were significantly down regulated in HCC and its decr...

Renal cell carcinoma (RCC) is the most prevalent malignancy of kidney and accounts for approximately 4% of all cancer diagnoses in adults. Previous studies demonstrated microRNA-195-5p (miR-195-5p) as a tumor suppressor which is deregulated in many human cancers. However, the role of miR-195-5p in RCC is largely unknown. In the present study, we demonstrated that miR-195-5p was downregulated an...