Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive biomarker.

Some pathogens block generation of reactive oxygen species to evade neutrophil killing, but how that is accomplished is poorly understood. In this issue of Cell Host & Microbe, Vareechon et al. (2017) describe ADP-ribosylation of Ras as a strategy to inhibit assembly of neutrophil NADPH oxidase.

M acroautophagy (hereafter referred to as autophagy) or ‘self-eating’ is a lysosomal degradation pathway and plays a role in the breakdown of disordered intracellular organelles, such as peroxisomes (pexophagy), mitochondria (mitophagy), endoplasmic reticula (reticulophagy) and ribosomes (ribophagy), as well as providing for controlled recycling of macromolecules during cellular adaption and pa...

Parkinson disease (PD) is a neurodegenerative disease that affects more than 5 million people worldwide and one in hundred people over the age of 60. PD is both a chronic and degenerative disorder that is characterized by loss of dopaminergic neurons in the substantia nigra, associated with the formation of fibrillar aggregates composed of synuclein and other proteins (Lees et al., 2009). PD i...

A set of monoclonal antibodies was constructed by immunising mice with peptide fragments of the c-myc oncogene product. One such antibody, Myc 1-6E10 was shown to bind to a 62,000 dalton protein identifiable with the c-myc product (p62c-mYc). The antigen recognised was not destroyed by paraflin wax embedding. Myc 1-6E10 was used to characterise the distribution of p62C-fYC in archival testicula...

Rzeźnik et al. [1] in their recent paper published in ‘Kardiologia Polska’ found that revascularisation of unilateral or bilateral renal artery stenosis (RAS) leads to improvement in several echocardiographic parameters reflecting heart structure and function, as well as impacts on plasma transforming growth factor β1 (TGFβ1) and B-type natriuretic peptide. At least some of the effects on the h...

An analytic study was conducted on coupled partial differential equations. We formally derived new solitary wave solutions of generalized coupled system of Zakharov-Kuznetsov (ZK) and KdV equations by using modified extended tanh method. The traveling wave solutions for each generalized coupled system of ZK and KdV equations are shown in form of periodic, dark, and bright solitary wave solution...

Graz University of Technology, Institute of Environmental Biotechnology, Petersgasse 12, A6 8010 Graz, Austria; Julius Kühn-Institut (JKI), Messeweg 11, D-38104 Braunschweig, 7 Germany, Kawanda Agricultural Research Institute, National Banana Research Program, 8 Uganda; Makerere University, Department of Agricultural Production, College of 9 Agricultural and Environmental Sciences, Uganda and B...

The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exerci...

The author contends that sex differentials in childhood mortality in Pakistan are a likely outcome of son preference behavior by parents. Consideration is given to the historical improvement in the female disadvantage in mortality, the neglect of female children, gender and class factors, and son preference and high fertility. Data are from the 1981 Pakistan census and other official surveys....