The authors report and discuss a case of bilateral renal artery stenosis in a hypertensive 9 year-old girl that was first suspected with Technetium-dimercaptosuccinic acid renal scintigraphy. The scintigraphy showed signs of acute renal failure while the patient was on enalapril for controlling her hypertension. Bilateral renal artery stenosis was confirmed with computed tomography angiography....

Although the dioxin receptor, the aryl hydrocarbon receptor (AhR), is considered a major regulator of xenobiotic-induced carcinogenesis, its role in tumor formation in the absence of xenobiotics is still largely unknown. Trying to address this question, we have produced immortalized cell lines from wild-type (T-FGM-AhR+/+) and mutant (T-FGM-AhR-/-) mouse mammary fibroblasts by stable co-transfe...

The guanine nucleotide binding protein Ras plays a central role as molecular switch in cellular signal transduction. Ras cycles between a GDP-bound "off" state and a GTP-bound "on" state. Specific oncogenic mutations in the Ras protein are found in up to 30% of all human tumors. Previous 31P NMR studies had demonstrated that in liquid solution different conformational states in the GDP-bound as...

The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exerci...

RAS and BRAF mutations are associated with worse outcomes for patients colorectal cancer (CRC) liver metastases, but little is known about their effects on resectability, conversion, resection rates. The prospective Finnish RAXO-study (NCT01531621) included 1086 treatable metastatic CRC 2012-2018 (Osterlund TLRHE 2021, Isoniemi BJS 2021) of which 354 RAS/BRAFV600E status liver-limited metastase...

30 INTRODUCTION Gastroesophageal reflux disease (GERD) is defined as the occurrence of chronic symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. The most common symptom is heartburn, experienced by 10% of the United States population daily and by 40% at least once monthly (1). In addition, it is estimated that more than 40 million people use over...

Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS. Methods: In this randomized...

Background and purpose: Metadiscourse markers (MDMs) play a significant role in academic witting. They act as a bridge between writers and readers and make a text more understandable. Therefore, this study aimed at investigating the use of MDMs in introduction, methods, results, and discussion (IMRaD) sections of English medical research articles (RAs) published in Iranian and American ISI jour...