Patients with known coagulation deficiencies, either congenital or acquired, may bleed spontaneously with trauma or with surgical intervention. In contrast, however, are the unchallenged patients who bleed in a variety of clinical settings that demand rapid diagnosis so that appropriate therapy can be instituted. In the first section Dr. Louis M. Aledort demonstrates a series of vignettes of ac...

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental ...

more than 65 years old, and the use of antiplatelet agents is vastly more common than that. Patients with inherited bleeding disorders will likely present to the emergency department (ED) for treatment of abnormal bleeding at some point during their lifetime, and ED visits for bleeding in patients who are taking antithrombotic agents are not uncommon. The clinician must be familiar with these d...

Bleeding disorders and thromboembolic diseases represent abnormalities of the hemostatic mechanism. As this mechanism is basically a defense device against the loss of blood from the vascular system, any serious breakdown can bring about life-threatening hemorrhages. The author describes the inherent problems involved in these cases; and since many of the recognized congenital and acquired blee...

sons, except in a limited role of reference for a specific topic. It is an excellent book for the biologist, particularly the aquatic biologist, and is highly recommended for their general use. In addition it is a fine reference for those concerned with developing, establishing, and planning programs of water pollution control. It is unfortunate that the word "control" has been used in the titl...

Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations. Clinical phenotypes range from asymptomatic condition-even in homozygous subjects-to severe life-threatening bleedings (central nervous system, gastroi...

BACKGROUND AND OBJECTIVES Acquired von Willebrand syndrome (AVWS) is a rare acquired disorder. In most cases it is associated with lymphoproliferative disorders and monoclonal gammopathies, while less frequently myeloproliferative disorders (MPD) are involved. Although bleeding is the most important symptom, thrombotic complications have also been observed in cases associated with MPD. Our aim ...