Traditionally the physician's absolute right to decide what treatment any individual patient should be oVered has been the Holy Grail of clinical practice since the earliest of time. Such a decision has clearly always been influenced by individual physician experience, and the presented or published results of fellow practitioners. The first medical research trials to investigate the use of pat...

BACKGROUND Interventions for dietary and physical activity changes in obese adults may be less effective for participants with additional obesity-related risk factors and co-morbidities than for otherwise healthy individuals. This study aimed to test the feasibility and acceptability of the recruitment, allocation, measurement, retention and intervention procedures of a randomised controlled tr...

BACKGROUND Few interventions are proven to increase recruitment in clinical trials. Recruitment to RESTART, a randomised controlled trial of secondary prevention after stroke due to intracerebral haemorrhage, has been slower than expected. Therefore, we sought to investigate an intervention to boost recruitment to RESTART. METHODS/DESIGN We conducted a stepped-wedge, cluster randomised trial ...