A random forest (RF) predictor is an ensemble of individual tree predictors. As part of their construction, RF predictors naturally lead to a dissimilarity measure between the observations. One can also define an RF dissimilarity measure between unlabeled data: the idea is to construct an RF predictor that distinguishes the “observed” data from suitably generated synthetic data. The observed da...

O-glycosylation of mammalian proteins is one of the most important post-translational modifications (PTMs). Hence, there is significant interest in the development of computational methods for reliable prediction of O-Glycosylation sites from amino acid sequences. One particular challenge in training the classifiers comes from the fact that the available dataset is highly imbalanced, which make...

We study random cutting down of a rooted tree and show that the number of cuts is equal (in distribution) to the number of records in the tree when edges (or vertices) are assigned random labels. Limit theorems are given for this number, in particular when the tree is a random conditioned Galton–Watson tree. We consider both the distribution when both the tree and the cutting (or labels) are ra...

The Golgi Apparatus (GA) is a major collection and dispatch station for numerous proteins destined for secretion, plasma membranes and lysosomes. The dysfunction of GA proteins can result in neurodegenerative diseases. Therefore, accurate identification of protein subGolgi localizations may assist in drug development and understanding the mechanisms of the GA involved in various cellular proces...

Power quality signal feature selection is an effective method to improve the accuracy and efficiency of power quality (PQ) disturbance classification. In this paper, an entropy-importance (EnI)-based random forest (RF) model for PQ feature selection and disturbance classification is proposed. Firstly, 35 kinds of signal features extracted from S-transform (ST) with random noise are used as the ...

In view of the essential role played by dosRS in the survival of Mycobacterium in the infected granuloma cells, dosRS transcriptional regulatory proteins were considered as a validated target for high throughput screening (HTS). However, the cost and time factor involved in screening large compound libraries are an important hurdle in identifying lead compounds. Therefore, the use of computatio...

Random Forest (RF) is an ensemble classification technique that was developed by Breiman over a decade ago. Compared with other ensemble techniques, it has proved its accuracy and superiority. Many researchers, however, believe that there is still room for enhancing and improving its performance in terms of predictive accuracy. This explains why, over the past decade, there have been many exten...

Accurate speed prediction is a crucial step in the development of a dynamic vehcile activated sign (VAS). A previous study showed that the optimal trigger speed of such signs will need to be pre-determined according to the nature of the site and to the traffic conditions. The objective of this paper is to find an accurate predictive model based on historical traffic speed data to derive the opt...

This article presents a regression-tree-based meta-analysis of rodent pulmonary toxicity studies of uncoated, nonfunctionalized carbon nanotube (CNT) exposure. The resulting analysis provides quantitative estimates of the contribution of CNT attributes (impurities, physical dimensions, and aggregation) to pulmonary toxicity indicators in bronchoalveolar lavage fluid: neutrophil and macrophage c...

Topic of the research is exploration and fusion of non-invasive measurements for an accurate detection of pathological larynx. Measurements for human subject encompass results of a specific survey and information extracted by openSMILE toolkit from several audio recordings of sustained phonation (vowel /a/). Clinical diagnosis, assigned by medical specialist, is a target attribute for binary cl...