نتایج جستجو برای: rag1

تعداد نتایج: 1083  

Journal: :Annals of the rheumatic diseases 2013
Qingyu Cheng Imtiaz M Mumtaz Laleh Khodadadi Andreas Radbruch Bimba F Hoyer Falk Hiepe

OBJECTIVES We have previously shown that both short- and long-lived plasma cells (PCs) significantly contribute to autoantibody production in NZB/W mice as a model of lupus nephritis. The aim of this study was to determine the role of autoreactive long-lived (memory) PCs refractory to immunosuppression and B cell depletion in the pathogenesis of systemic lupus erythematosus. METHODS Splenic C...

Journal: :Circulation 2006
Zequan Yang Yuan-Ji Day Marie-Claire Toufektsian Yaqin Xu Susan I Ramos Melissa A Marshall Brent A French Joel Linden

BACKGROUND We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bone marrow transplantation to show that the infarct-sparing effect of A2AR activation at reperfusion is primarily due to effects on bone marrow-derived cells. In this study we show that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury. METHOD AND RESULTS After a 45-minute oc...

2017
Mayilaadumveettil Nishana Namrata M Nilavar Rupa Kumari Monica Pandey Sathees C Raghavan

Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome. RAG1, a critical enzyme involved in V(D)J recombination exhibits structural similarity to HIV integrase. We find that two integrase inhibitors, Raltegravir and Elvitegravir, interfered with the physiological func...

2011
Masahito Kamanaka Samuel Huber Lauren A. Zenewicz Nicola Gagliani Chozhavendan Rathinam William O'Connor Yisong Y. Wan Susumu Nakae Yoichiro Iwakura Liming Hao Richard A. Flavell

The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated transgenic mice expressing a dominant-negative IL-10 receptor specifically in T cells (CD4dnIL-10Rα). We found that Foxp3-depleted CD45RB(lo) (regulatory T cell [T(reg) cell]-depleted CD45RB(lo)) but not CD45RB(hi) CD4(+) T cells are controlled directly by IL-10 upon transfer int...

Journal: :Journal of economic entomology 2012
S L Wiarda W R Fehr M E O'Neal

Aphis glycines Matsumura (Hemiptera: Aphididae) can reduce the yield of aphid-susceptible soybean (Glycine max (L.) Merrill) cultivars. The Rag1 and Rag2 genes conferresistance to some biotypes of A. glycines. These genes individually can limit population growth of A. glycines and prevent yield loss. The impact of these genes when combined is not known. We compared the development of A. glycine...

Journal: :Journal of the American Society of Nephrology : JASN 2011
Oliver M Steinmetz Shaun A Summers Poh-Yi Gan Timothy Semple Stephen R Holdsworth A Richard Kitching

Although Th17 responses may contribute to the pathogenesis of glomerulonephritis, whether the key transcription factor in Th17 cell development, RORγt, also promotes glomerulonephritis is unknown. Here, we induced crescentic glomerulonephritis in wild-type and RORγt-deficient (RORγt(-/-)) mice. RORγt(-/-) mice were protected from disease, with reduced histologic and functional injury and decrea...

Journal: :Infection and immunity 2011
Maurício Bandeira Cleiton S Santos Everton C de Azevedo Luciane Marieta Soares Júlio O Macedo Samyra Marchi Caroline Luane R da Silva Adenizar D Chagas-Junior Alan J A McBride Flávia W C McBride Mitermayer G Reis Daniel A Athanazio

The aims of this study were to investigate the frequency of pulmonary hemorrhage (PH) in mice unable to produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene (Inos) knockout (KO) on the frequency/severity of interstitial nephritis in vivo. We studied the outcome of infection by the virulent Leptospira interrogans serovar Copenhageni strain C...

2009
Radhashree Maitra Moshe J. Sadofsky

More than one-third of the RAG1 protein can be truncated from the N-terminus with only subtle effects on the products of V(D)J recombination in vitro or in a mouse. What, then, is the function of the N-terminal domain? We believe it to be regulatory. We determined, several years ago, that an included RING motif could function as an ubiquitin E3 ligase. Whether this activity is limited to automo...

2012
Guannan Wang Kajari Dhar Patrick C. Swanson Marcia Levitus Yung Chang

During V(D)J recombination, the RAG1/2 recombinase is thought to play an active role in transferring newly excised recombination ends from the RAG post-cleavage complex (PCC) to the non-homologous end joining (NHEJ) machinery to promote appropriate antigen receptor gene assembly. However, this transfer mechanism is poorly understood, partly because of the technical difficulty in revealing weak ...

Journal: :Proceedings of the National Academy of Sciences 2007

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