نتایج جستجو برای: rag 2 mutation

تعداد نتایج: 2746580  

Journal: :Annual review of genetics 2011
David G Schatz Patrick C Swanson

V(D)J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development through a series of carefully orchestrated DNA breakage and rejoining events. DNA cleavage requires a series of protein-DNA complexes containing the RAG1 and RAG2 proteins and recombination signals that flank the recombining gene segments. In this review, we discuss recent advances in our unders...

Journal: :Journal of immunology 1998
H Nishina L Radvanyi K Raju T Sasaki I Kozieradzki J M Penninger

The dual specificity kinase SEK1 (MKK4) is a direct activator of stress-activated protein kinases (SAPK/JNK) in response to environmental stresses or mitogenic factors. We show in Sek1(-/-)Rag(-/-) chimeric mice that a Sek1 null mutation augments the susceptibility of peripheral T cells to TCR/CD3 religation-induced apoptosis. Sek1(-/-) T cells failed to induce expression of the death suppresso...

2013
Stefan Taube Abimbola O. Kolawole Marina Höhne John E. Wilkinson Scott A. Handley Jeffrey W. Perry Larissa B. Thackray Ramesh Akkina Christiane E. Wobus

UNLABELLED Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice deficient in recombination activation gene (Rag) 1 or 2 and common gamma chain (γc)...

2016
D. Passagem-Santos M. Bonnet D. Sobral I. Trancoso J.G. Silva V.M. Barreto A. Athanasiadis J. Demengeot J.B. Pereira-Leal

The RAG recombinase is a domesticated transposable element co-opted in jawed vertebrates to drive the process of the so-called V(D)J recombination, which is the hallmark of the adaptive immune system to produce antigen receptors. RAG targets, namely, the Recombination Signal Sequences (RSS), are rather long and degenerated sequences, which highlights the ability of the recombinase to interact w...

Journal: :PLoS Biology 2003
Jeroen P Roose Maximilian Diehn Michael G Tomlinson Joseph Lin Ash A Alizadeh David Botstein Patrick O Brown Arthur Weiss

Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligand-independent signaling by the precursors of mature antigen receptors regulates development of B and T lymphocytes. Here we describe a basal signal...

Journal: :Molecular cell 2013
Zhi-Yang Tsun Liron Bar-Peled Lynne Chantranupong Roberto Zoncu Tim Wang Choah Kim Eric Spooner David M Sabatini

The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, its site of activation. The Rags are unusual GTPases in that they function as obligate heterodimers, which consist of RagA or B bound to RagC or D. ...

Journal: :Physiological research 2002
A Liptáková J Cársky O Ulicná O Vancová P Bozek Z Duracková

We studied the effects of administration of beta-resorcylidene aminoguanidine (RAG) to Wistar strain rats with experimental diabetes mellitus (DM) induced by streptozotocin. The effects studied included antioxidant levels in plasma and the liver, oxidative damage of lipids represented by the formation of substances reacting with thiobarbituric acid (TBARP) and selected biochemical indicators. T...

Journal: :Proceedings of the National Academy of Sciences 1994

Journal: :Cell reports 2015
Lawrence D Schweitzer William C Comb Liron Bar-Peled David M Sabatini

mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase is activated downstream of growth factor signaling. mTORC1 is brought to the lysosome by the Rag GTPases, which are tethered to the lysosomal memb...

Journal: :Cell 2010
Yasemin Sancak Liron Bar-Peled Roberto Zoncu Andrew L. Markhard Shigeyuki Nada David M. Sabatini

The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound compartment that contains the mTORC1 activator, Rheb. We show that amino acids induce the movement o...

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