Radiation therapy has been used in cancer treatment for many decades; although effective in killing tumor cells, ROS produced in radiotherapy threaten the integrity and survival of surrounding normal cells. Recent studies have indicated that some commonly used medicinal plants may be good sources of potent but non-toxic radioprotectors. The pomegranate, Punica granatum L., an ancient, mystical,...

background: microwave thermotherapy has been gradually used in radiotherapy and it is reported that microwave radiation increases bone demineralization rate independently of temperature. furthermore, it becomes more and more widespread that the damage caused by the synergistic effect of microwave radiation and hypergravity. the experiment was designed to investigate the effect of microwave radi...

background: astronauts will be exposed to both chronic space radiation and acute high doses of energetic radiation of solar particle events in long-term deep space missions. the application of radioprotectors in space missions has basic limitations such as their very short time window as well as their acute toxicity and considerable side effects. the aim of the present study was to investigate ...

background: currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. this study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated nmri mice. materials and methods: adult male nmri mice in groups of 10 were exposed to various doses of gamm...

Background: Currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. This study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated NMRI mice. Materials and Methods: Adult male NMRI mice in groups of 10 were exposed to various doses of gamm...

 ABSTRACTBackground: Radioprotective effects of famotidine, an antagonist of H2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. This study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis i...

abstractbackground: radioprotective effects of famotidine, an antagonist of h2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. this study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis in...

Background and Purpose: Epidemiological data suggests an excess risk of cardiovascular disease (CVD) at low doses (0.05 and 0.1 Gy) of ionizing radiation (IR). Furthermore, the underlying biological and molecular mechanisms of radiation-induced CVD are still unclear. Because damage to the endothelium could be critical in IR-related CVD, this study aimed to identify the effects of radiation on i...

Some chemical considerations have suggested that selenium-containing compounds should be good radioprotectors. Shimazu and Tappel reported that the selenoanalogues of cystine and methionine were effective in the radioprotection of proteins and amino acids in solution*. Earlier investigations in our labora­ tories have shown that selenourea has a radiopro­ tective effect in chemical systems 2, i...