Theranostics is a promising branch of nuclear medicine that uses radiopharmaceuticals for diagnosis and treatment cancer, immunotheranostics special area in it. The aim the study was to summarise potential theranostics visualisation tumour microenvironment elimination its immunosuppressive components. article presents up-to-date information on composition interaction various cell subpopulations...

Radiopharmaceuticals for functional renal imaging, including renal blood flow, renal blood volume, glomerular excretion, and metabolism have been available for some time. This review outlines radiopharmaceuticals for functional renal imaging as well as those that target pertinent molecular constituents of renal injury and repair. The angiotensin and endothelin receptors are particularly appeali...

With a current annual mortality rate of around 35% worldwide, infection remains a significant concern, and the diagnosis and localization of infectious foci is an important health issue. As an established infection-imaging modality, nuclear medicine plays a vital health-care role in the diagnosis and subsequent effective treatment of this condition. Despite the development of several newer radi...

context inherited and sporadic medullary thyroid cancer (mtc) is an uncommon and medically challenging malignancy. even if the extent of initial surgery is deemed adequate, the recurrence rate remains high, up to 50% in most series. measurement of serum calcitonin is important in the follow-up of patients with mtc, and reliably reflects the existence of the disease. evidence acquisition there i...

UNLABELLED Many groups have reported the adsorption or retention of (99m)Tc-radiopharmaceuticals on injection vials and disposable plastic syringes. Such an enormously high loss of radioactivity would result in poor images, radiation exposure, waste, and economic burdens. We therefore decided to investigate the extent of adsorption or retention of several (99m)Tc-radiopharmaceuticals on injecti...

In spite of the hazard due to the radiation exposure, preparation of 90Y- and 177Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of 177Lu- and 90Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluated and compared to a...

To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitt...

objective(s): gallium‐68 (ga‐68) is an ideal research and hospital‐based pet radioisotope. currently, the main form of ga‐68 radiopharmaceutical that is being synthesised in‐house is ga‐68 conjugated with dota based derivatives. the development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. here we report on our three...

Molecular imaging is commonly used to improve the diagnosis and treatment of cancer. Nuclear medicine offers cutting-edge procedures instruments, computers radiopharmaceuticals for various diseases, including oncology indications. The detailed images provided by positron emission tomography (PET) can accurately image biochemical or physiologic/pathologic phenomena.

The treatment of bone metastases remains a clinical challenge. Although a number of well-established agents, namely bisphosphonates and denosumab, are available to reduce the occurrence of skeletal-related events, additional cancer-targeted therapies are required to improve patients' prognosis and quality of life. This review focuses on novel targets and agents that are under clinical evaluatio...