Bone marrow, spleen, liver and kidney proton transverse relaxation rates (R2), together with cardiac R2* from patients with sickle cell disease (SCD), paroxysmal nocturnal hemoglobinuria (PNH) and non-transfusion dependent thalassemia (NTDT) have been compared with a control group. Increased liver and bone marrow R2 values for the three groups of patients in comparison with the controls have be...

Introduction: Transverse relaxation rates, R2 and R2* and the apparent diffusion coefficient (ADC) are all typically estimated from the exponential decay of MR signal magnitude as a function of either echo time (for R2 and R2*) or b-value (for ADC). Changes in R2 and R2* induced by ultrasmall paramagnetic iron oxide (USPIO) contrast agents, along with ADC, have recently been utilised to estimat...

R2 elements are non-long-terminal-repeat (non-LTR) retrotransposons that insert specifically in the 28S rRNA genes of many insects. Previous reports concerning this element in the genus Drosophila have suggested that R2 elements are absent from many species of this genus, particularly those species from the subgenus Drosophila. In this report, we present an extensive study of the distribution a...

Accurate R2* measurements are critical for many abdominal imaging applications. Conventionally, R2* maps are derived via the monoexponential fitting of signal decay within a series of gradient-echo (GRE) images reconstructed from multichannel datasets combined using a root sum-of-squares (RSS) approach. However, the noise bias at low-SNR TEs from RSS-reconstructed data often causes the underest...