BACKGROUND Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant results and whether the proportion of trials with significant results differs ...

Advances in information technology and near ubiquity of the Internet have spawned novel modes of communication and unprecedented insights into human behavior via the digital footprint. Health behavior randomized controlled trials (RCTs), especially technology-based, can leverage these advances to improve the overall clinical trials management process and benefit from improvements at every stage...

BACKGROUND Only four out of 31 completed randomized controlled trials (RCTs) of HIV prevention strategies against sexual transmission have shown significant efficacy. Poor adherence may have contributed to the lack of effect in some of these trials. In this paper we explore the impact of various levels of adherence on measured efficacy within an RCT. ANALYSIS We used simple quantitative metho...

BACKGROUND A criticism of Randomized Controlled Trials (RCTs) in primary care is that they lack external validity, participants being unrepresentative of the wider population. Our aim was to determine whether published primary care-based RCTs report information about how the study sample is assembled, and whether this is associated with RCT characteristics. METHODS We reviewed RCTs published ...

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© 2013 Kean et al.; licensee BioMed Central Lt Commons Attribution License (http://creativec reproduction in any medium, provided the or References 1. Kean JD, Camfield D, Sarris J, Kras M, Silberstein R, Scholey A, Stough C: A randomized controlled trial investigating the effects of PCSO-524(R), a patented oil extract of the New Zealand green lipped mussel (perna canaliculus), on the behaviour...

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In order to make statistical inference, that is drawing conclusions from a sample to describe a population, it is crucial to know the correct distribution of the data. This paper focused on censored data from the normal distribution. The purpose of this paper was to answer whether we can test if data comes from a censored normal distribution. This by using normality tests and tests designed for...