نتایج جستجو برای: quinolinic acid

تعداد نتایج: 747454  

Journal: :Medical physics 2011
Sonja Dieterich Carlo Cavedon Cynthia F Chuang Alan B Cohen Jeffrey A Garrett Charles L Lee Jessica R Lowenstein Maximian F d'Souza David D Taylor Xiaodong Wu Cheng Yu

The task group (TG) for quality assurance for robotic radiosurgery was formed by the American Association of Physicists in Medicine's Science Council under the direction of the Radiation Therapy Committee and the Quality Assurance (QA) Subcommittee. The task group (TG-135) had three main charges: (1) To make recommendations on a code of practice for Robotic Radiosurgery QA; (2) To make recommen...

2015
Katsumi Shibata Junko Hirose Tsutomu Fukuwatari

Tryptophan metabolism is directly involved with B-group vitamins such as vitamin B2, niacin, and vitamin B6, and indirectly with vitamin B1 and pantothenic acid. We evaluated the validity of requirements of B-group vitamins set by the Dietary Reference Intakes for the Japanese (DRI-J). We investigated the fate of dietary tryptophan in 10 Japanese adult men who ate the same diet based on DRI-J d...

2012
Chiaki Hiratsuka Tsutomu Fukuwatari Katsumi Shibata

The purpose of this study was to determine, using the high-performance liquid chromatographic methods recently modified by us, the fate of dietary tryptophan in 17 healthy female Japanese adults who ate self-selected food. The experimental period was 22 days. The habitual intake of tryptophan was 3328.4 μmol/day. 24-hour urine samples were collected at the beginning of the experiment and then o...

2013
Rafael Lugo-Huitrón Perla Ugalde Muñiz Benjamin Pineda José Pedraza-Chaverrí Camilo Ríos Verónica Pérez-de la Cruz

Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is often implicated in the pathogenesis of a variety of human neurological diseases. QUIN is an agonist of N-methyl-D-aspartate (NMDA) receptor, and it has a high in vivo potency as an excitotoxin. In fact, although QUIN h...

Journal: :Clinical chemistry 1998
M Huengsberg J B Winer M Gompels R Round J Ross M Shahmanesh

An alternative pathway of Trp metabolism involves the conversion of Trp to kynurenine by indoleamine-2,3-dioxygenase, which leads to synthesis of the neurotoxin, quinolinic acid. This study explores the relationship of indoleamine-2,3-dioxygenase activity with stages of HIV infection. Sera from 206 HIV-positive and 72 seronegative subjects were analyzed for Trp and kynurenine. The kynurenine-to...

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