Chapter Outline Introduction 123 Therapeutic Potential of Monoamine Oxidase Inhibition in Neurological Disorders 124 Depression 125 Parkinson’s Disease 126 Other Neurodegenerative Diseases 126 Smoke and Alcohol Cessation 127 Alkaloids as Monoamine Oxidase Inhibitors 127 Indole Alkaloids 128 Isoquinoline Alkaloids 134 Piperidine Alkaloids 137 Desoxypeganine 138 Other Alkaloids 139 Conclusion 141...

The formation of Cu(II) complexes with two isomeric quinoline-containing scorpiand-type ligands has been studied. The ligands have a tetraazapyridinophane core appended with an ethylamino tail including 2-quinoline (L1) or 4-quinoline (L2) functionalities. Potentiometric studies indicate the formation of stable CuL(2+) species with both ligands, the L1 complex being 3-4 log units more stable th...

Alkaloids in the skin glands of poison frogs serve as a chemical defense against predation, and almost all of these alkaloids appear to be sequestered from dietary arthropods. Certain alkaloid-containing ants have been considered the primary dietary source, but dietary sources for the majority of alkaloids remain unknown. Herein we report the presence of approximately 80 alkaloids from extracts...

In spite of the wide use of quinine in the treatment of malaria, and of quinidine in the therapy of cardiac arrhythmias, little information exists concerning the metabolic fate of the cinchona alkaloids administered to man. As early as 1869, Kerner (1) isolated from the urine of subjects receiving quinine a substance thought to be quinetine, a derivative of quinine in which the vinyl side chain...

An efficient one-pot, three-component method for the preparation of indeno[1,2-b]quinoline-9,11(6H,10H)-dione, acridine-1,8(2H,5H)-dione and various multi-substituted quinoline-3-carbonitrile derivatives has been developed through the Michael addition to enaminones, which was achieved by both microwave irradiation and conventional heating.

This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids from microbial, plant and animal sources. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, including ants, amphibians and beetles...

Choisya 'Aztec-Pearl', a hybrid of Choisya ternata and Choisya dumosa var. arizonica, had the antinociceptive activity in the ethanol extract (EECA) of its leaves evaluated. Two quinoline alkaloids, anhydroevoxine (A) and choisyine (C), isolated from these leaves were also tested. The results obtained pointed out to a very high antinociceptive activity measured by the hot plate model for EECA (...

s: I. Wölfling J, Bóna Á, Frank É, Schneider G, Berényi Á, Zupkó I. Synthesis and cytotoxic activity of 16-benzylidene estrone 3-methyl ethers. Hungarian-AustrianCzech-German-Greek-Italian-Polish-Slovak-Slovenian Joint Meeting on Medicinal Chemistry, 24-27. June, 2009, Budapest, Hungary. II. Zupkó I, Berényi Á, Marchais-Oberwinkler S, Frotscher M. Direct antiproliferative effect of novel nonste...

In spite of the wide use of quinine in the treatment of malaria, and of quinidine in the therapy of cardiac arrhythmias, little information exists concerning the metabolic fate of the cinchona alkaloids administered to man. As early as 1869, Kerner (1) isolated from the urine of subjects receiving quinine a substance thought to be quinetine, a derivative of quinine in which the vinyl side chain...

Professor Ariens in another context1 (and elsewhere in this Symposium) has drawn attention to the possibilities of molecular pharmacology serving as a guide to the development of new drugs. In pursuit of this theme, I should like to examine with you later in this lecture some of the biological and molecular characteristics of the principal non-steroid anti-inflammatory drugs known to us today, ...