• Quinine binds to quininedependent antibodies first and causes CDR loop reconfiguration. • A hybrid paratope consisting of quinine and reconfigured CDR recognizes its target epitope. Drug-induced immune thrombocytopenia (DITP) is caused by antibodies that react with specific platelet-membrane glycoproteinswhen the provokingdrug is present.More than 100 drugs have been implicated as triggers fo...

developed fever, and was sent to hospital. In hospital he had daily attacks of ague, for which he was treated with quinine, " eight pills three times a day." The quinine caused deafness, but as the fever was not influenced he was shipped to Jamaica on his way to England. During the voyage he was still treated with quinine, but the fever became worse, and he was disembarked at Kingston and sent ...

Behavioral and electrophysiological studies suggest that rats can identify a taste stimulus with a single lick, in <200 ms. However, the conditions under which these conclusions were drawn varied widely across experiments. We designed a series of experiments to assess the effects of the number of licks of a tastant that are available, tastant concentration and prior learning experience on the s...