Introduction A wide array of processes occurs after spinal cord injury, including white matter demyelination and proximal and distal Wallerian degeneration. The demyelination and interruption of the axonal tract ultimately leads to the functional loss seen in spinal cord injuries. Therefore it is important to have a non-invasive technique that is able to track myelin in spinal cords. There are ...

Quantitative MRI measures of multiexponential T(2) relaxation and magnetization transfer were acquired from six samples of excised and fixed rat spinal cord and compared with quantitative histology. MRI and histology data were analyzed from six white matter tracts, each of which possessed unique microanatomic characteristics (axon diameter and myelin thickness, in particular) but a relatively c...

OBJECTIVES To assess in vivo the volume and the magnetization transfer magnetic resonance imaging (MRI)-detectable damage of the cervical cord gray matter in patients with relapsing-remitting multiple sclerosis (RRMS) and to evaluate whether such damage correlates with disability. DESIGN Cervical cord conventional and magnetization transfer MRI scans were acquired from 18 patients with RRMS (...

PURPOSE To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect. METHODS Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhanc...

Background Quantitative myocardial T1 mapping shows promise for assessment of various cardiomyopathies. Most available sequences are generally acquired within a breath-hold using a balanced SSFP (bSSFP) imaging readout. However, the signal obtained from a bSSFP imaging readout is T2 dependent, sensitive to magnetization transfer and has increased susceptibility to the B0 field inhomogeneity lea...

BACKGROUND AND PURPOSE The differential diagnosis of Parkinson syndromes remains a major challenge. Quantitative MR imaging can aid in this classification, but it is unclear which of the proposed techniques is best suited for this task. We, therefore, conducted a head-to-head study with different quantitative MR imaging measurements in patients with IPS, MSA-type Parkinson, PSP, and healthy eld...

Introduction: The Achilles tendon is commonly involved in mechanical, degenerative and inflammatory disease. Ultrashort echo time (UTE) imaging allows the tendon to be directly imaged, even when normal or only mildly diseased [1]. Off resonance saturation has been used for introducing contrast into UTE images; near resonance this reflects T2 whereas far from resonance magnetization transfer (MT...

BACKGROUND Studies on treatment resistant depression (TRD) using advanced magnetic resonance imaging techniques are very limited. METHODS A group of 15 patients with clinically defined TRD and 15 matched healthy controls underwent magnetization transfer imaging (MTI) and T1-weighted (T1W) imaging. MTI data were processed and analyzed voxel-wised in SPM2. A voxel based morphometric (VBM) analy...

An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnetization transfer effects since the B1 field of the labeling coil did not exten...