OBJECTIVES The aim of this study was to investigate whether prolongation of the heart rate-corrected QT interval (QTc) is an independent risk factor for predicting future acute coronary syndrome (ACS) occurrence or mortality in patients with at least one cardiac risk factor presenting with chest pain to the emergency department (ED). METHODS This is a single-center, retrospective study of pat...

BACKGROUND QTc prolongation and Torsade de Ppointes have been reported in patients on methadone maintenance. OBJECTIVES In this study, QTc was compared before and after the veteran (n = 49) was on a stable dosage of methadone for 8.72 ± 4.50 years to treat heroin dependence. Risk factors were correlated with the QTc once the veteran was on a stable dose of methadone. Differences in the clinic...

Introduction: Patients with type 2 diabetes mellitus (DM) are at increased risk of dying from cardiovascular diseases. Elevated cardiovascular risk in this population persists even after other conventional cardiovascular risk factors are eliminated or reduced, suggesting that there are other, incompletely understood, mechanisms which are increasing cardiovascular risk in such patients. Ventricu...

Background : Prolonged QTc interval is one of the side effects short-regimen MDR-TB. QTcprolongation a risk factor for Torsades de pointes and influenced by many factors. Case 47-year-oldwoman who was diagnosed with MDR-TB through GeneXpert examination received short-regimenMDR-TB. This patient experienced repeated prolongation, peak 600 msec occurringat 4th month mild hypokalemia without clini...

Cardiovascular complication should be evaluated in patient with T1DM. Ventricular instability (QT abnormalities) in Type 1 Diabetes Melitus (T1DM) is a risk factor for mortality. Prolongation of corrected QT interval (QTc) is accurate and the most sensitive test for the autonomic neuropathy whether QT interval dispersion (QTd) in arrhythmia is a predictor for mortality. This study is to evaluat...

Following the ICH E14 clinical evaluation guideline [1], the measurement of QT/QTc interval prolongation has become the standard surrogate biomarker for cardiac drug safety assessment and the faith of a drug development. In Thorough QT (TQT) study, a so-called positive control is employed to assess the ability of this study to detect the endpoint of interest, i.e. the QT prolongation by about f...