In the title compound, C19H18N4O4, the nitro-phenyl and phenyl rings are twisted by 67.0 (6) and 37.4 (4)°, respectively, with respect to the pyrazole ring plane [maximum deviation = 0.0042 (16) Å]. The dihedral angle between the mean planes of the phenyl rings is 59.3 (3)°. The amide group, with a C-N-C-C torsion angle of 177.54 (13)°, is twisted away from the plane of the pyrazole ring in an ...

with steroidal and non-steroidal anti inflammatory drugs (NSAIDs). NSAIDs are drug with analgesic, antipyretic and in higher doses anti inflammatory effects. They inhibit synthesis of inflammation mediators. Most NSAIDs act as non-selective inhibitors of the enzyme cyclooxygenase (COX), by inhibiting the metabolism of arachidonic acid. COX catalyses the formation of prostaglandins (PGs) and thr...

In the title compound, C(26)H(24)BrN(3)O(2), the isoxazolidine ring adopts an envelope conformation, the ring N atom deviating from the mean plane of the other four atoms by an angle of 0.286°. The orientation of the phenyl ring is +sp and the bromophenyl ring is +sc relative to the attached pyrazole ring; the dihedral angles between the least-squares planes of the pyrazole and the attached phe...

The title compound, C(21)H(17)N(3), crystallizes with the phenyl ring in the 3-position coplanar with the pyrazole ring within 4.04 (5)°, whereas the phenyl ring in the 5-position forms a dihedral angle of 50.22 (3)° with the pyrazole ring. There is no ambiguity regarding the position of pyridine N atom, which could have exhibited disorder between the ortho positions of the ring.

In the title compound, C(19)H(17)ClN(4)O(2)S, the dihedral angle between the pyrazole and phenyl rings is 43.3 (3)°. The bridging unit between the pyrazole and methoxyphenyl rings is planar within 0.0169 Å and makes dihedral angles of 2.3 and 26.4°, respectively, with these two rings. This conformation is influenced by intramolecular N-H⋯O and N-H⋯Cl hydrogen bonds. The crystal packing is stabi...

The title compound, [Li2(C25H23BN4OP)2], features a centrosymmetric dimeric complex. The four-memberered Li2O2 ring is exactly planar due to symmetry. The Li atom is four-coordinated by two O atoms and by two N atoms of two different pyrazole rings. The dihedral angle between two pyrazole rings bonded to the same B atom is 45.66 (9)°. The B-N-N-Li-N-N metalla ring adopts a boat conformation. Th...

The title compound, C(12)H(8)Cl(2)N(4)O, was synthesized by the reaction of 5-amino-1-(4-chloro-phen-yl)-1H-pyrazole-3-carbonitrile and 2-chloro-acetyl chloride. The dihedral angle between the pyrazole and benzene rings is 30.7 (3)°. In the crystal structure, strong N-H⋯O hydrogen bonds link the mol-ecules into chains along [001]. C-H⋯N hydrogen bonds are also present.

The 1H-pyrazole-3-carboxylic acid 2 was converted in good yield (69%) into the corresponding 1H-pyrazole-3-carboxamide 5 via reaction of the acid chloride 3 with 2,3- diaminopyridine (4). A different product, the 3H-imidazo[4,5-b] pyridine derivative 6, was formed from the reaction of 3 with 4 and base in benzene for 5 hours. The structures of the synthesized compounds were determined spectrosc...

The structure of 4-chloro-1 H -pyrazole, C 3 ClN 2 , at 170 K has orthorhombic ( Pnma ) symmetry and is isostructural to its bromo analogue. Data were collected low temperature since -pyrazole sublimes when subjected the localized heat produced by X-rays. displays intermolecular N—H...N hydrogen bonding packing features a trimeric molecular assembly bisected mirror plane m normal b running thro...

Herein, new substituted ligands based on pyrazole (L1–L4) were synthesized via a one-step by condensing (1H-pyrazole-1-yl) methanol with different primary amine compounds. The present work utilized the catalytic properties of in situ complexes formed these various copper (II) salts viz. Cu(CH3COO)2, CuSO4, CuCl2, and Cu(NO3)2 for oxidation catechol to o-quinone. studies showed that activities d...