The mechanisms by which receptors guide intracellular virus transport are poorly characterized. The murine polyomavirus (Py) binds to the lipid receptor ganglioside GD1a and traffics to the endoplasmic reticulum (ER) where it enters the cytosol and then the nucleus to initiate infection. How Py reaches the ER is unclear. We show that Py is transported initially to the endolysosome where the low...

In the title dinuclear iridium(III) complex, [Ir(2)(C(10)H(15))(2)(C(5)H(5)N(2)S)(2)]I(2), the iridium(III) atoms are bridged by 2-(aminosulfanyl)pyridine(1-) [(2-py)SNH] ligands in a μ-(2-py)SNH-κ(2)N(py),N(NH):κN(NH) mode. The dinuclear complex cation lies on a crystallographic inversion center, resulting in a planar Ir(2)N(2) ring with an Ir-N(py) bond length of 2.085 (9) Å and bridging Ir-N...

The interaction of β- and γ-cyclodextrins (β-CD and γ-CD, respectively) with polyacrylamide modified with pyrenyl (Py) residues (pAAmPy) was investigated in a mixed solvent of water and dimethyl sulfoxide (DMSO) by steady-state fluorescence. In the absence of CD, the fluorescence spectra indicated that the formation of Py dimers became less favorable with increasing volume fraction of DMSO (x(D...

Pyrrole-imidazole (Py-Im) polyamides are nuclease-resistant novel compounds that inhibit gene expression by binding to the minor groove of DNA. A Py-Im polyamide that targets rat TGF-beta1 was designed as a gene-silencing agent for progressive renal diseases, and the distribution and the effects of this polyamide on renal injury were examined in Dahl-salt sensitive (Dahl-S) rats. For identifica...

The advancement of DNA-based bionanotechnology requires efficient strategies to functionalize DNA nanostructures in a specific manner with other biomolecules, most importantly peptides and proteins. Common DNA-functionalization methods rely on laborious and covalent conjugation between DNA and proteins or peptides. Pyrrole-imidazole (Py-Im) polyamides, based on natural minor groove DNA-binding ...

The cation, anion, and solvent in the title compound, [K(C(18)H(36)N(2)O(6))][Co(C(8)H(12))(C(16)H(10))(2)]·0.5C(5)H(12), are well separated. The pentane solvent mol-ecules are found in channels along [100] and were modeled as disordered over crystallographic inversion centers. Using the mid-points of the coordinated olefins, the angle between the C(py)/C(py)-Co-C(py)/C(py) and the C(cod)/C(cod...

Abstract It is generally accepted that some trace organic contaminants (TrOCs) pass through the wastewater treatment process without being properly treated and find their way into waterbodies. These molecules can also be concentrated within biosolids (BS) adsorption. The presence of TrOCs in BS, which are then commonly used as soil amendments agriculture, may affect plant growth viability. pote...

The combined use of di-2-pyridyl ketone ((py)2CO) with various diols in Mn cluster chemistry has afforded five new compounds, namely, [Mn11O2(OH)2{(py)2CO2}5(pd)(MeCO2)3(N3)3(NO3)2(DMF)4](NO3)∙2DMF∙H2O (1∙2DMF∙H2O), [Mn11O2(OH)2{(py)2CO2}5(mpd)(MeCO2)3(N3)3(NO3)2(DMF)4](NO3) (2), [Mn12O4(OH)2{(py)2CO2}4(mpd)2(Me3CCO2)4(NO3)4(H2O)6](NO3)2∙2MeCN (3∙2MeCN), [Mn4(OMe)2{(py)2C(OMe)O}2(2-hp)2(NO3)2(D...

Using ligands based on either an acetylacetonate or a dipyrrin moiety appended with pyridyl groups, a series of novel heteroleptic copper(II) and cobalt(III) complexes combining both chelate units such as (acacpy(2))Cu(dpm-py) and (acacpy(2))Co(dpm-py)(2) (acacpy(2) = 1,3-bis(4-pyridyl)-1,3-propanedionate; dpm-py = 5-(4-pyridyl)dipyrrin) have been prepared and fully characterized. These two com...