نتایج جستجو برای: purine metabolism

تعداد نتایج: 233577  

Journal: :Annals of the rheumatic diseases 2002
A E van Ede R F J M Laan R A De Abreu A B J Stegeman L B A van de Putte

OBJECTIVES To study (a) purine metabolism during treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA) and (b) the relation of purine metabolism with efficacy and toxicity of MTX treatment. METHODS One hundred and three patients with active RA who started treatment with MTX were included. The initial MTX dosage was 7.5 mg/week and raised to a maximum of 25 mg weekly if ...

Journal: :Journal of Cardiology 2021

Uric acid, the end-product of purine metabolism in humans, is not only a cause gout, but also may play roles developing cardiovascular diseases such as hypertension, atrial fibrillation, chronic kidney disease, heart failure, coronary artery and death. Several clinical investigations have reported serum uric acid predictive marker for outcomes. Although causal relationship hyperuricemia to rema...

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