نتایج جستجو برای: pulmonary emphysema
تعداد نتایج: 229383 فیلتر نتایج به سال:
Alpha 1 antitrypsin deficiency predisposes subjects to developing pulmonary emphysema and childhood liver cirrhosis. We have studied restriction fragment length polymorphisms (RFLPs) of the alpha 1 antitrypsin gene in a normal population and a group of patients with pulmonary emphysema. We have identified five RFLPs with eight restriction enzymes. The most frequent polymorphisms have been detec...
A personalized approach to the treatment of a polygenic disease, such as pulmonary emphysema, provides unique opportunities for selection effective in each clinical case. Progress understanding molecular mechanisms behind emphysema allows take new look at classification, causes phenotype variability, prognosis and preventive measures before manifestation. The aim this review was bring together ...
Alphai-antitrypsin (aiAT) deficiency states, which predispose one to the development of pulmonary emphysema, have been described with increasing frequency. While the precise physiologic role of this protein is not known, it appears certain that it protects the lung from proteolytic digestion by a number of enzymes. Data are now available which mimic this situation in the experi mental animal a...
INTRODUCTION Chronic Obstructive Pulmonary Disease (COPD) is characterized by high morbidity and mortality. Lung computed tomography parameters, individually or as part of a composite index, may provide more prognostic information than pulmonary function tests alone. AIM To investigate the prognostic value of emphysema score and pulmonary artery measurements compared with lung function parame...
The chronic obstructive pulmonary disease (COPD) encompasses two phenotypically related diseases, chronic bronchitis and emphysema [1-2]. Although the hallmark of COPD is inflammation and inability to maintain efficient gas exchange, emphysema is often characterized by atypical over-distension of the alveoli and permanent destruction of the surrounding supporting structures leading to irreversi...
Eight weeks after a single intravenous injection of trypsin, more than half of 26 treated rats showed pulmonary emphysema, as demonstrated by a significant increase of the mean linear intercept (MLI = 107 microns) in comparison with 11 controls (69 +/- 15 microns) (mean +/- SD). As observed 56 days after the injection, the intraperitoneal administration of trypsin (24 rats) also leads to lung e...
RATIONALE Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema. OBJECTIVES We evaluated the correlation of total cross-sect...
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