background: the role of thyroid hormones has been recognized in normal embryo development many years ago. these hormones also affected the development of reproductive organs and their activity. objectives: this study was conducted to investigate the effect of inducing hypothyroidism by propyl-2-thiouracyl (ptu) on lambs testicular histomorpho-logy and plasma testosterone concentration. methods:...

Introducción: la orbitopatía tiroidea (OT) es una manifestación frecuente de enfermedad Graves. En el embarazo, Graves no controlada representa un reto para tratamiento por los riesgos que puede ocasionar a madre y al feto. Objetivo: revisión actualizada en embarazo. Metodología: búsqueda PubMed, Lilacs Scielo, incluyendo literatura publicada hasta 2022, tanto inglés como español. Discusión: af...

effect of propylthiouracil (ptu)-induced hypothyroidism during the prepubertal period, at a dose of oneg per kg of the diet, on serum testosterone level and seminal characteristics of fars indigenous chickens wasstudied. ptu was fed between 7th to 13th weeks of age and semen was collected at weekly intervals, starting at 21st week of age and continued for seven weeks. the effect of ptu treatmen...

Amaç: Bu çalışma ile sıçanlarda 6-n-propil-2-tiourosil (PTU) hipotiroidi oluşturularak bozulan uzamsal öğrenme ve bellek performansına selenyumun (Se) iyileştirici etkisini ortaya koymak amaçlanmıştır. Gereç Yöntem: Çalışma vücut ağırlıkları 250-300 gr olan, genç erkek Wistar albino sıçanlar üzerinde yapıldı. Sıçanlar kontrol (Kontrol), (PTU), PTU berabler 5 ppm Se verilen (P-5Se) 10 (P-10Se) o...

The ipsilateral retinothalamic projection in Xenopus laevis normally first appears at about stage 54, at a time when a number of other changes known to be dependent on a rise in circulating levels of thyroxine begin to occur. We have investigated the role of thyroxine in the development of the ipsilateral retinothalamic projection by studying retinal projections and patterns of retinal histogen...

Organic iodides have been shown to induce thyroid hypertrophy and increase alterations in colloid in rats, although the mechanism involved in this toxicity is unclear. To evaluate the effect that free iodide has on thyroid toxicity, we exposed rats for 2 weeks by daily gavage to sodium iodide (NaI). To compare the effects of compounds with alternative mechanisms (increased thyroid hormone metab...

The aim of this study was to compare renal impairment in patients with propylthiouracil (PTU)-induced small-vessel vasculitis and patients with primary anti-neutrophil cytoplasmic antibody (ANCA)-induced small-vessel vasculitis. The study compared the pathology and clinical conditions of 10 patients with PTU-associated small-vessel vasculitis and 18 patients with primary ANCA-associated small-v...

OBJECTIVE The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were incl...

Objectives It was aimed to compare the cyclic fatigue resistances of ProTaper Universal (PTU), ProTaper Next (PTN), and ProTaper Gold (PTG) and the effects of sterilization by autoclave on the cyclic fatigue life of nickel-titanium (NiTi) instruments. Materials and Methods Eighty PTU, 80 PTN, and 80 PTG were included to the present study. Files were tested in a simulated canal. Each brand of ...