Different authors of the product-service bundle literature agree on the fact that business models are central to implement PSS successfully. However, most of the studies about PSS business models mention its importance but do not explore which content should compose such models. Furthermore, PSS business models are explored taking into account a partial view of business model dimensions. Finall...

Background. Primary Sjögren's syndrome (PSS) is a frequent systemic autoimmune disease. In this study, we aimed to explore the cognitive impairment and the correlations with brain MRI. Methods. Twenty-five patients (mean age 55 ± 11.8 years, 21 females) with PSS were prospectively selected and tested with a French translation of the Brief Repeatable Battery for Neuropsychological Examination. T...

Primary Sjögren's syndrome (pSS) is characterized by a panel of autoantibodies, while it is not clear whether B cells and autoantibodies play an essential role in pathogenesis of the disease. Here, we report a novel mouse model for pSS which is induced by immunization with the Ro60_316-335 peptide containing a predominant T cell epitope. After immunization, mice developed several symptoms mimic...

We have for the first time found that completely insulating Halloysite nanotubes (HNTs) significantly enhance electrical conductivity of PEDOT/PSS films by simply mixing. Based on this accident finding we have created highly porous and conductive PEDOT/PSS films hybridized with the HNTs. Through further optimization of the mixing condition we have obtained flexible and conductive hybrid films w...

UNLABELLED Aqueous dispersion of conductive polymer poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) ( PEDOT PSS) was deposited on spin-coated and drop cast nanofibrillar cellulose (NFC)-glycerol (G) matrix on a glass substrate. A thin glycerol film was utilized on plasma-treated glass substrate to provide adequate adhesion for the NFC-glycerol (NFC-G) film. The effects of annealing te...

We evaluated cellular responses to polymer-treated gold nanorods, which were synthesized using the standard wet-chemistry method that utilizes hexadecyltrimethylammonium bromide (CTAB). The nanorod dispersions were coated with either polystyrene sulfonate (PSS) or polyethylene glycol (PEG). Two sizes of nanorods were tested, with optical responses peaking at 628 and 773 nm. The cells were from ...

B cell-activating factor (BAFF) has a key role in promoting B-lymphocyte activation and survival in primary Sjögren's syndrome (pSS). The cellular origin of BAFF overexpression in salivary glands of patients with pSS is not fully known. We investigated whether salivary gland epithelial cells (SGECs), the main targets of autoimmunity in pSS, could produce and express BAFF. We used quantitative R...

BACKGROUND Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren's syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have mainly been studied with culture that typically recovers only 65% of the bacteria present. OBJECTIVE This study was to use high throughput sequencing, covering both cultivated ...

Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease with well-documented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with...

While small dynamic firms propose PSS applications based on new technologies quite easily, large infrastructures are often required. SMEs don’t have the capacity to do this alone. For complex systems, different SMEs combine efforts to build an efficient infrastructure. Other SMEs can join and propose other PSS, creating a network. As networks grow the SMEs must understand their place within the...