Besides hypoxia, other factors and molecules such as lactate, succinate, and reactive oxygen species activate transcription factor hypoxia-inducible factor-1 (HIF-1) even in normoxia. One of the main target gene products of HIF-1 is carbonic anhydrase IX (CA IX). CA IX is overexpressed in many tumors and serves as prognostic factor for hypoxic, aggressive and malignant cancers. CA IX is also in...

Thrombin decreases the platelet surface expression of the glycoprotein (GP) Ib-IX complex. To determine whether this effect is reversible, flow cytometric studies were performed with GPlb-IX-specific monoclonal antibodies. In both whole blood and washed platelet systems, incubation of platelets with thrombin or a combination of adenosine diphosphate and epinephrine resulted in a maximal decreas...

background: as glass ionomers have the ability to reload fluoride from outside sources, the aim was to compare the recharge pattern of six glass ionomer cements after exposure to fluoride. materials and methods: fuji vii, fuji ix, riva pink, riva bleach, ketac fil and fuji ix extra were investigated. the fluoride-containing materials used were tooth paste and mouth wash (colgate). specimens of ...

vii Preface ix Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Publications during doctorate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi

The field measurement equipment that provides reliable results is essential in the quality verification of DVB-H networks. In addition, sufficiently in-depth analysis of the post-processed data is important. This paper is based on [12] and presents a method to collect and analyze the key performance indicators of the DVB-H radio interface, using a mobile device as a measurement and data collect...

This work reviews a number of existing computational studies concentrated on the question of how spoken language can be learned from continuous speech in the absence of linguistically or phonetically motivated background knowledge, a situation faced by human infants when they first attempt to learn their native language. Specifically, the focus is on how phonetic categories and word-like units ...

This is the appendix to the paper Temporal Analysis of Static Priority Preemptive Scheduled Cyclic Streaming Applications using CSDF Models [1]. The temporal analysis approach presented in [1] makes use of an iterative algorithm that computes so-called maximum busy periods over multiple task phases. The algorithm contains a stop criterion indicating after which iteration of the algorithm subseq...

Replacement therapy for hemophilia B (factor IX deficiency) using prothrombin complex concentrate (PCC) has been associated with serious complications of thromboembolic events and transmission of viral infections. Monoclonal antibody-purified factor IX (Mononine) provides a highly purified factor IX concentrate, while eliminating other vitamin K-dependent factors (II, VII, and X). Mononine was ...

The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the proteasefactor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported a 2-fold increase in velocity index (slope) and peak thrombin concentration, whereas factor IX R23...

Hypoxia may play an important role in the pathogenesis of systemic sclerosis (SSc). Carbonic anhydrase IX (CA IX) is one of the hypoxia markers and its extracellular domain can be released into the serum. However, the clinical significance of serum CA IX levels in SSc is still unknown. The aim of this study is to evaluate the possibility that serum CA IX levels can be a specific disease marker ...