One of the most commonly observed surface structures on the prokaryotic cell envelopes is monomolecular crystalline array of proteinaceous subunits termed Surface Layers or S-layers. Due their self assembly ability and the highly ordered, regular structure down to the nanometer scale, S-layers were demonstrated to possess a great potential for nanobiotechnological applications. Some probiotic b...

Protein banding pattern of eight snakeheads – Channa species viz., Channa striatus, Channa marulius, Channa punctatus, Channa diplogramme, Channa bleheri, Channa gachua, Channa stewartii and Channa aurantimaculata collected from different regions of India were used to study the phylogenetic relationship among them. The banding pattern from muscle protein indicated a unique profile for each spec...

Cancer is a disease that still difficult to identify up today. One of the causes cancer genetic modification because mutations in p53 gene. Healthy cells have wild type protein (normal) able manage DNA separation. If mutates, it will be detect composition has changed. Bioinformatics combination biology and information engineering (TI) utilized data. applications data mining bioinformatics devel...

We have developed a fully automated protein design strategy that works on the entire sequence of the protein and uses a full atom representation. At each step of the procedure, an all-atom model of the protein is built using the template protein structure and the current designed sequence. The energy of the model is used to drive a Monte Carlo optimization in sequence space: random moves are ei...

Nucleosomes have been fractionated on nondenaturing polyacrylamide gels, and nucleosome subtypes containing the Drosophila melanogaster specific protein D l and ubiquitinated core histone H2A were identified by solubility in 0.1 M NaCl before nucleoprotein gel electrophoresis. Nucleosomes which contain DNA complementary to the 1.672 density simple satellite (sequence -AATAT-) bind protein D l ,...

A Procedure for fast pattern matching in protein sequences is presented. It uses a biological metric, based on the substitution matrices as PAM or BLOSUM, to compute the matching. Biological sensitive pattern matching does pattern detection according to the available empirical data about similarity and affinity relations between amino acids in protein sequences. Sequence alignments is a string ...

A comprehensive package of software has been developed to access nucleic acid and protein sequence databases on stand-alone IBM personal computers. The software combines keyword search on the annotation fields of the data with pattern matching algorithms on the biological sequences. Sequences containing complex sites like promoters or kink sites can be identified as well as sequences that are s...