One of the challenges to understand the organization of the nervous system has been to determine how axon guidance molecules govern axon outgrowth. Through an unbiased genetic screen, we identified a conserved Wnt pathway which is crucial for anterior-posterior (A/P) outgrowth of neurites from RME head motor neurons in Caenorhabditis elegans. The pathway is composed of the Wnt ligand CWN-2, the...

In any safety engineering effort, deriving safety requirements is a key activity. Doing this for autonomous systems (AS) is challenging. However, several existing techniques can be pulled together to create a reasonable approach The risk of interaction between implemented requirements remains a concern, as does ambiguity about the appropriate boundary of the AS system. We believe these issues c...

1Department of General Surgery, Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, PR China, 233004 2University of Mississippi Cancer Institute, Jackson, MS, USA, 39216 3Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA, 48201 4Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui, PR...

BACKGROUND Despite awareness that comparative analysis of patient safety data from several data sources would promote risk reduction, there has been little effort to establish an incident classification system that is generally applicable to patient safety data in European primary care. OBJECTIVE To describe the development of a patient safety incident classification system for primary care. ...

In genome-scale RNA interference (RNAi) screens, it is critical to control false positives and false negatives statistically. Traditional statistical methods for controlling false discovery and false nondiscovery rates are inappropriate for hit selection in RNAi screens because the major goal in RNAi screens is to control both the proportion of short interfering RNAs (siRNAs) with a small effec...

This study investigates the intricacies between the player interface proposed by the screens, (in particular on smartphone applications or in video games) and gambling. Recent research indicates connections between "immersion" and excessive screen practice. We want to understand the causal-effects between online gambling and the "immersion" variable and understand their relationship and its con...

RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multiple orthologous RNAi reagents (MORR). In addition to being traditionally validat...

Visual inspection of cells is a fundamental tool for discovery in biological science. Modern robotic microscopes are able to capture thousands of images from massively parallel experiments such as RNA interference (RNAi) or small-molecule screens. Such screens also benefit from lab automation, making large screens, e.g., genome-scale knockdown experiments, more feasible and common. As such, the...

PURPOSE In this study, the authors examined diagnostic and intervention services for children identified with hearing loss (HL) after the newborn period. METHOD The authors compared ages at service delivery and length of delays between service delivery steps for 57 later-identified children with HL and 193 children who referred for assessment from the newborn hearing screen (NHS). For only la...

AIM To identify the specialties from which trainee prescribers come and to determine their pre-training and post-training concerns about prescribing and how they are utilising their prescribing skills. METHOD A self-report profile questionnaire including open and closed questions, some Likert-type scales and a 24-item, self-report follow-up questionnaire were used. RESULTS Half of the nurse...