Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase.

The study focused on effect of capacity building programme of development agencies on well being of beneficiaries in Niger Delta Nigeria. Data was collected with the aid of structured questionnaire from 271 randomly selected participants involved in capacity building programmes in Niger Delta area of Nigeria. Data were analysed using mean scores and Z test statistics. Findings revealed that bef...

In this paper we describe a solution phase peptide synthesis strategy using the 4-nitrobenzenesulfonamido/N-methyl-4-nitrobenzenesulfonamido group as a protecting/activating system of the carboxyl function. The 4-nitrobenzenesulfonamido group is stable during peptide chain elongation (Fmoc chemistry). The N-aminoacyl or N-dipeptidyl-4-nitrobenzensulfonamides, when activated by methylation, can ...

Fragments of pectic polysaccharides rhamnogalacturonan-II (RG-II) and apiogalacturonan were synthesised using p-tolylthio apiofuranoside derivatives as key building blocks. Apiofuranose thioglycosides can be conveniently prepared by cyclization of the corresponding dithioacetals possessing a 2,3-O-isopropylidene group, which is required for preservation of the correct (3R) configuration of the ...

A short and efficient synthesis of 2'-O-methoxyethylguanosine (8) is described. Central to this strategy is the development of a novel silicon-based protecting group (MDPSCl(2), 2) used to protect the 3',5'-hydroxyl groups of the ribose. Silylation of guanosine with 2 proceeded with excellent regioselectivity and in 79% yield. Alkylation of the 2'-hydroxyl group of 6 proceeded with methoxyethyl...

DMB (Dimethylbarbituric) and DETB (Diethylthiobarbituric) are both barbituric thiobarbituric acid derivatives respectively, that forms enamines with the Nα amine of amino acids. These compounds were found to be stable crystalline solids show stability in standard acidic basic conditions used for solid-phase peptide synthesis (SPPS) strategies. protecting groups cleaved by a mild solution 2 % hy...

The Frege-Russell view is that existence is a second-order property rather than a property of individuals. One of the most compelling arguments for this view is based on the premise that there is an especially close connection between existence and number. The most promising version of this argument is by C.J.F. Williams (1981, 1992). In what follows, I argue that this argument fails. I then de...

In this paper, a practical approach for the total synthesis of kipukasin A is presented with 22% overall yield by using tetra-O-acetyl-β-D-ribose as starting material. An improved iodine-promoted acetonide-forming reaction was developed to access 1,2-O-isopropylidene-α-D-ribofuranose. For the first time, ortho-alkynylbenzoate was used as protecting group for the 5-hydoxy group. After subsequent...