Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in brain and heart. HCN channels are principally activated by membrane hyperpolarization and binding of cAMP. Here, we identify tyrosine phosphorylation by Src kinase as another mechanism affecting channel...

Plant growth promoting rhizobacteria produce chemical compounds with different benefits for the plant. Among them, HCN is recognized as a biocontrol agent, based on its ascribed toxicity against plant pathogens. Based on several past studies questioning the validity of this hypothesis, we have re-addressed the issue by designing a new set of in vitro experiments, to test if HCN-producing rhizob...

We have imaged the central ∼ 1 kpc of the circumnuclear starburst disk in the galaxy NGC253 in the HCN(1→0), HCO(1→0), and CO(1→0) transitions at 60 pc resolution using the Owens Valley Radio ObservatoryMillimeter-Wavelength Array (OVRO). We have also obtained Atacama Pathfinder Experiment (APEX) observations of the HCN(4→3) and the HCO(4→3) lines of the starburst disk. We find that the emissio...

We present results from an observing campaign of the molecular content of the coma of comet C/1999 S4 (LINEAR) carried out jointly with the millimeter arrays of the Berkeley-Illinois-Maryland Association (BIMA) and the Owens Valley Radio Observatory (OVRO). Using the BIMA array in autocorrelation (‘‘single-dish’’) mode, we detected weak HCN J 1⁄4 1 0 emission from comet C/1999 S4 (LINEAR) at 14...

Cloud storage system poses new challenges to the community to support efficient concurrent querying tasks for various data-intensive applications, where indexes always hold important positions. A practical method is proposed to construct a two-layer indexing scheme for multi-dimensional data in diverse server-centric cloud storage system. RT-HCN is proposed, which is an indexing scheme integrat...

Hyperpolarization-activated cyclic nucleotide-gated "HCN" channels, which underlie the hyperpolarization-activated current (Ih), have been proposed to play diverse roles in neurons. The presynaptic HCN channel is thought to both promote and inhibit neurotransmitter release from synapses, depending upon its interactions with other presynaptic ion channels. In larvae of Drosophila melanogaster, i...

Coal is a major contributor to the global emission of nitrogen oxides (NOx). The NOx formation during coal utilization typically derives from the thermal decomposition of N-containing compounds (e.g., pyrrolic groups). NH₃ and HCN are common precursors of NOx from the decomposition of N-containing compounds. The existence of H₂O has significant influences on the pyrrole decomposition and NOx fo...

We report deep K-band (18-27GHz) observations with the 100-m Green Bank Telescope of HCN(1 − 0) line emission towards the two submillimeterselected galaxies (SMGs) SMMJ02399−0136 (z = 2.81) and SMMJ16359+6612 (z = 2.52). For both sources we have obtained spectra with channel-to-channel rms noise of σ ≤ 0.5mJy, resulting in velocity-integrated line fluxes better than < ∼ 0.1 Jy km s , although w...

Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3',5'-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs). The cardiac "funny current" (If) is among the cAMP-sensitive effectors that drive pacemaking in SAMs. If is produced by hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels. Voltage-dependent gati...