The widespread adoption of on-board volumetric imaging in cancer radiotherapy has stimulated research efforts to develop online adaptive radiotherapy techniques to handle the inter-fraction variation of the patient's geometry. Such efforts face major technical challenges to perform treatment planning in real time. To overcome this challenge, we are developing a supercomputing online re-planning...

Background. To assess the feasibility of salvage intensity-modulated radiation Therapy (IMRT) and to examine clinical outcome. Patients and Methods. 57 patients were treated with salvage IMRT to the prostate bed in our center from January, 2007, to February, 2010. The mean prescription dose was 68 Gy in 34 fractions. Forty-four patients received concomitant androgen deprivation. Results. Doses ...

Cancer, which is the uncontrolled division of cells, a leading fatal disease in world with high mortality rates. It can be treated using several methods, including radiotherapy, involves ionizing radiation. Radiotherapy on basis source placement has two types, i.e. brachytherapy and external beam radiotherapy. External radiotherapy evolved from 2-D conventional therapy to 3-D Conformal (3D-CRT)...

PURPOSE New treatments are introduced routinely into clinical practice without rigorous economic analysis. The specific aim of this study was to examine the cost effectiveness of proton beam radiation compared with current state-of-the art therapy in the treatment of patients with prostate cancer. MATERIALS AND METHODS A Markov model was informed with cost, freedom from biochemical failure (F...

This work aims at three goals: first, to define a set of statistical parameters and plan structures for a 3D pretreatment thoracic and prostate intensity-modulated radiation therapy (IMRT) quality assurance (QA) protocol; secondly, to test if the 3D QA protocol is able to detect certain clinical errors; and third, to compare the 3D QA method with QA performed with single ion chamber and 2D gamm...

BACKGROUND To assess the benefits of bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. METHODS Two IMRT plans, with and without EUD constraints on the bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients....

Purpose Although proton beam therapy (PBT) is a rapidly expanding modality to treat prostate cancer compared with intensity modulated radiation (IMRT), data comparing disease control outcomes and patterns of failure in the postprostatectomy setting remain substantially limited. Methods Materials All patients who underwent postoperative IMRT or PBT bed only at single institution were included (2...

background: to correct patient positioning errors (setup errors) during prostate cancer treatment using epid and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. materials and methods: fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field imrt planning technique. the p...

PURPOSE Intensity-modulated radiotherapy (IMRT) is delivered using a variety of techniques with differing temporal dose characteristics. Spatial dose metrics are generally used to evaluate treatment plan quality. However, the use of this information alone neglects the effects of the significant differences in dose delivery duration and dose accumulation patterns, both of which can impact cell s...

PURPOSE/OBJECTIVES Current Radiation Therapy Oncology Group (RTOG) guidelines for pelvic radiation therapy are based on general anatomic boundaries. Sentinel lymph node (SLN) imaging can identify potential sites of lymph node involvement. We sought to determine how tailored radiation therapy fields for prostate cancer would compare to standard RTOG-based fields. Such individualized radiation th...