نتایج جستجو برای: prostate gland
تعداد نتایج: 175580 فیلتر نتایج به سال:
Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 prostate-derived cDNAs to profile transcripts regulated by androgens in prostate cancer cells. This study identified a novel gene that we have de...
BACKGROUND High-intensity focused ultrasound (HIFU) is a minimally-invasive treatment for nonmetastatic prostate cancer. OBJECTIVE To report medium-term outcomes in men receiving primary whole-gland HIFU from a national multi-centre registry cohort. DESIGN, SETTING, AND PARTICIPANTS Five-hundred and sixty-nine patients at eight hospitals were entered into an academic registry. INTERVENTIO...
Background: Prostate cancer is the most common malignancy among the male population in the United States and the 3rd most common non-skin cancer among men in Iran. Its prevalence has shown a rising trend in recent decades. The aim of this study was to report the epidemiological features of prostate cancer in patients referred for prostate biopsy in the south of Iran and to evaluate the accuracy...
1. A comparison was made of the binding of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and cyclic AMP in the rat prostate gland. Distinct binding mechanisms exist for these compounds, and cyclic AMP cannot serve as a competitor for the 5alpha-dihydrotestosterone-binding sites and vice versa. In contrast with the results obtained with 5alpha-dihydrotestosterone, very small...
The developing prostate gland is regulated by its hormonal milieu, most notably androgens, which dictate its growth and differentiation (Price, 1936; Lasnitzki and Mizuno, 1980). In addition, the developing prostate is sensitive to estrogenic exposures (Price, 1963). During prostate morphogenesis, elevated levels of endogenous estrogens (maternal or excess local production) or exogenous estroge...
Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking. In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasi...
The application of magnetic resonance imaging (MRI) in detecting and localizing prostate cancer lends itself naturally to 3D volume rendering, allowing the physician to observe the entire gland and navigate at will. While MR images can be obtained with good intra-slice resolution, inter-slice gaps are significantly larger. Because of this, when visualizing a prostate segmented from MR image sli...
∗ This work was supported in part by National Science Foundation CAREER award IIS 0133471 and NSF ITR award 0312709. Mr. James Hing is a graduate student in the PRISM laboratory (e-mail: [email protected]). Dr. Ari D. Brooks is a General Surgeon specializing in Surgical Oncology at Drexel University College of Medicine (email: [email protected]). Dr. Jaydev P. Desai is the Director of...
BACKGROUND The prostate is a key gland in the sexual physiology of male mammals. Its sensitivity to steroid hormones is widely known, but its response to prolactin is still poorly known. Previous studies have shown a correlation between sexual behaviour, prolactin release and prostate physiology. Thus, here we used the sexual behaviour of male rats as a model for studying this correlation. Henc...
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