RATIONALE In a modified methacholine provocation test that was used to study changes in airway responsiveness to occupational irritants or sensitizers in healthy subjects, two protocols were used: a long protocol (doubling methacholine concentrations between dose steps) or a short protocol (fourfold increases in concentration). This modified methacholine provocation allows measurements of the p...

It is known that, in Condorcet's classical jury model, the proportion of jurors supporting a decision is not a significant indicator of that decision's reliability: the probability that a particular majority decision is correct given the majority size depends only on the absolute margin between the majority and the minority, and is invariant under changes of the proportion in the majority if th...

Valproic Acid for TBI Engagement in Meaningful Activities Interpreters’ Challenges EOL Discussions Goals and Preferences of Older Adults ACP Patients with Cirrhosis Children's Regrets After Sibling Death Psychiatric Symptomology COVID Rave Reviews Administration Cases Traumatic Brain Injury Background: brain injury (TBI) remains a major source morbidity mortality the US worldwide.1,2 Can valpro...

Neuroendocrine (NE) differentiation is a common feature in prostate cancer (PC). The clinical significance of this phenomenon is controversial; however preclinical and clinical data are in favor of an association with poor prognosis and early onset of a castrate resistant status. NE PC cells do not proliferate, but they can stimulate the proliferation of the exocrine component through the produ...

Perinatal hypoxia-ischemia (HI) results in brain injury, whereas mild hypoxic episodes result in preconditioning, which can significantly reduce the vulnerability of the brain to subsequent severe hypoxia-ischemia. Hypoxic-preconditioning (PC) has been shown to enhance cell survival and differentiation of progenitor cells in the central nervous system (CNS). The purpose of this study was to det...