BACKGROUND The influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo-steady state concentration of alfentanil on the pharmacokinetics of propofol. METHODS The pharmacokinetics of propofol were studied on two occasions in eight male volunteers in a randomized crossover manner with a 3-week interval. While volunte...

BACKGROUND The mechanism by which general anesthetics, widely used in clinical practice for over 160 years, effects on sensory responsiveness has been unclear until now. In the present study, the authors sought to explore the effect of different doses of propofol on somatosensory cortex by whisker stimulation in rats. METHODS In a fixed cage, rats were anesthetized with propofol 80 mg/kg intr...

The study was conducted in 60, ASA grade I & II patients for BIS guided sedation during middle ear surgery under local anesthesia. All patients were Pre medicated with Inj. Fentanyl 2μgm/kg and Glycopyrolate 5μg/kg, 10 minutes before surgery. Local anesthesia was given by the experienced ENT surgeon using lidocaine 2% with adrenaline 1:200,000. Patients were randomly divided into two groups. Gr...

Propofol (2,6-diisopropylphenol), being used as an intravenous sedative and anesthetic agent, influences not only upon nervous system but also for host inflammatory response through modulating neutrophil functions. This study is designed to evaluate the modulating effects of propofol and its lipid carrier administration at clinically relevant rate on canine neutrophil functions. Clinically heal...

Retrospective cohort study. Data was collected from medical records June 2018 to September 2019 for consecutive patients aged 18 and older undergoing elective laparoscopic sleeve gastrectomy obesity. A standardized ERAS pathway bariatric surgery utilized in all study patients. For anesthetic maintenance, the OFA group (n = 46) received propofol combined with dexmedetomidine, lidocaine, and/or k...

Propofol and midazolam were compared in 40 patients undergoing orthopaedic surgery under spinal anaesthesia. An infusion of either 1% propofol or 0.1% midazolam was given at a rate adjusted to maintain a similar level of sedation. The mean time to reach this required level was similar in both groups. Quality and ease of control of sedation were good in all patients. A mean infusion rate of 3.63...

BACKGROUND Alterations of the normal redox balance might be attributed to increase of plasma free-radical concentration and a disruption of the antioxidant defense system. One of the adverse effects of general anaesthetics is the exogen sources of reactive oxygen radicals that are responsible for several diseases. The purposes of the current study were to evaluate the effect of propofol on oxid...