The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two t...

Speed and position control systems for marine vehicles have been subject to an increased focus with respect to performance and safety. An example is represented by drilling operations performed with semi submersible rigs where the control of position and heading requires high accuracy. Drifting from the well position could cause severe damage to equipment and environment. Also, the use of under...

background and aims. wound dehiscence after lower third molar surgery extends the postoperative treatment period and may cause long-standing pain. the aim of this study was to compare wound dehiscence after removal of wisdom teeth in the most prevalent mandibular impaction (mesioangular class ib) by two different soft tissue flap designs. materials and methods. partially-erupted mandibular thir...

Speed and position control systems for marine vehicles have been subject to an increased focus with respect to performance and safety. An example is represented by drilling operations performed with semi submersible rigs where the control of position and heading requires high accuracy. Drifting from the well position could cause severe damage to equipment and environment. Also, the use of under...

This study investigates the unsteady dynamics and inherent instabilities of a cavitating propeller operating in a water tunnel. First, the steady characteristics of the cavitating propeller such as the thrust coefficient are obtained by applying continuity and momentum equations to a simple one-dimensional flow tube model. The effects of the tunnel walls as well as those of the propeller operat...

BACKGROUND AND PURPOSE Fluid-attenuated inversion recovery hyperintense vessels in stroke represent leptomeningeal collateral flow. We presumed that FLAIR hyperintense vessels would be more closely associated with arterial stenosis and perfusion abnormality in ischemic stroke on T2-PROPELLER-FLAIR than on T2-FLAIR. MATERIALS AND METHODS We retrospectively reviewed 35 patients with middle cere...

Introduction: Fast-spin echo (FSE) imaging is one of the most frequently used pulse sequences for brain imaging due to its scan time efficiency, good tissue contrast, and high effective resolution. Practical problems that occur are mostly due to patient motion, which leads to blurring and imaging ghosting (Fig. 1b). To make the acquisition robust to motion, the T2-w PROPELLER pulse sequence can...