A blood examination was carried out in order to assess the serum zinc level in a patient with taste dysfunction. A blood cell count was also performed simultaneously and promyelocytic leukemia was identified. This case provides an example of leukemia being detected at the time of a blood test being given to assess taste dysfunction.

Differentiation syndrome (DS) represents a life acute promyelocytic leukemia (APL) undergoing induction therapy with all (ATRA) or arsenic trioxide (ATO). It affected about 20 definitive diagnostic criteria. Clinically, DS is characterized by weight gain, fever not attributable to infection, respiratory distress, cardiac involvement, hypotension, and/or acute renal failure. At the histological ...

Fusion proteins of retinoic acid receptor ! (RAR!) with promyelocytic leukemia protein (PML-RAR!) or with promyelocytic leukemia zinc finger protein (PLZFRAR!) are associated with and likely responsible for the development of acute promyelocytic leukemia. These oncoproteins retain the ability to bind DNA and retinoic acid through the RAR! moiety. This enables them to repress RAR! target genes i...