Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were app...

abstract aims: regular physical activity can reduce the burden of chronic diseases, such as heart disease, diabetes, and some cancers, and can prevent early death. this study examined the impact of performing health promotion model intervention on physical activity of the health volunteers. materials & methods: this cross-sectional research is part of a three-month intervening study started in ...

Fasting has numerous biological, physical and mental health advantages or that as some physicians cure their patients by prescribing fasting to them. Fasting protects people from many diseases such as cancer, cardiovascular diseases, and diabetes complications. The main health-promoting effects of fasting are increased production of neurotrophic factors, neuroendocrine activation, hormetic stre...

Purpose: The prognosis of melanoma depends on early diagnosis and timely treatment. Autophagy plays a dual role in tumor progression. In the stages, it prevents formation, while advanced stages promotes tumorigenicity. This study aimed at investigating autophagy different evaluating relationship between clinicopathological factors. Methods: ATG5 BECN1 genes expression tumors were evaluated retr...

The strong storyline behind the critical role of cyclin-dependent kinase (CDK) inhibitor proteinsin natural defense against malignant transformation not only represents a heroic perspective forthese proteins, but also provides a bright future for the application of small molecule inhibitorsof CDKs in the novel cancer treatment strategies. The results of the present study revea...

The strong storyline behind the critical role of cyclin-dependent kinase (CDK) inhibitor proteinsin natural defense against malignant transformation not only represents a heroic perspective forthese proteins, but also provides a bright future for the application of small molecule inhibitorsof CDKs in the novel cancer treatment strategies. The results of the present study revea...

Objective(s): Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the effect and the molecular basis of miR-103 on LPS-induced injuries in PC12 cells in vitro and SCI rats in vivo. Materials and Methods: PC12 cells were exposed to LPS to induce cell injuries to mimic the in ...

Hair shafts are formed by terminal differentiation of hair keratinocytes which synthesize and cross-link keratins keratin-associated proteins. Here we tested the hypothesis that maturation also involves coordinated degradation non-cytoskeletal proteins autophagy. To this end, deleted essential autophagy regulator Atg7 in epidermis skin appendages, including hair, determined proteome from fully ...

he inverse relationship between plasma highTdensity lipoprotein (HDL) cholesterol levels and the risk for development of atherosclerotic cardiovascular disease has led to extensive studies of HDL and its major apoprotein apolipoprotein A-I (apoA-I) with respect to their antiatherogenic role. The ability of HDL and apoA-I to promote the efflux of cholesterol from cells in peripheral tissues, inc...