نتایج جستجو برای: promoters

تعداد نتایج: 23523  

2015
Daniel Carbajo Shigeyuki Magi Masayoshi Itoh Hideya Kawaji Timo Lassmann Erik Arner Alistair R. R. Forrest Piero Carninci Yoshihide Hayashizaki Carsten O. Daub Mariko Okada-Hatakeyama Jessica C. Mar Ramani Ramchandran

Understanding how cells use complex transcriptional programs to alter their fate in response to specific stimuli is an important question in biology. For the MCF-7 human breast cancer cell line, we applied gene expression trajectory models to identify the genes involved in driving cell fate transitions. We modified trajectory models to account for the scenario where cells were exposed to differ...

2014
Sony Suhandono Ardha Apriyanto Nisa Ihsani

In plant genetic engineering, the identification of gene promoters leading to particular expression patterns is crucial for the development of new genetically modified plant generations. This research was conducted in order to isolate and characterize several new promoters from cassava (Manihot esculenta Crantz) elongation factor 1 alpha (EF1A) gene family.Three promoters MeEF1A3, MeEF1A5 and M...

2015
Anna Mantsoki Guillaume Devailly Anagha Joshi

In embryonic stem (ES) cells, developmental regulators have a characteristic bivalent chromatin signature marked by simultaneous presence of both activation (H3K4me3) and repression (H3K27me3) signals and are thought to be in a ‘poised’ state for subsequent activation or silencing during differentiation. We collected eleven pairs (H3K4me3 and H3K27me3) of ChIP sequencing datasets in human ES ce...

Journal: :Applied and environmental microbiology 2011
John Blazeck Leqian Liu Heidi Redden Hal Alper

The development of strong and tunable promoter elements is necessary to enable metabolic and pathway engineering applications for any host organism. Here, we have expanded and generalized a hybrid promoter approach to produce libraries of high-expressing, tunable promoters in the nonconventional yeast Yarrowia lipolytica. These synthetic promoters are comprised of two modular components: the en...

Journal: :Revista panamericana de salud publica = Pan American journal of public health 2007
Robert Partridge Lawrence Proano George Skarbek-Borowski David Bouslough Scott Cohen

Underserved regions in the developing world are challenging areas to provide emergency medical care. As populations in these often remote or isolated districts may have minimal access to regular health care, contacts with medical providers are frequently episodic and driven by an acute condition. Health promoters—practitioners who provide basic medical care and promote public health in numerous...

2015
Shanshan Li Junyang Wang Xiao Li Shouliang Yin Weishan Wang Keqian Yang

BACKGROUND Streptomycetes attract a lot of attention in metabolic engineering and synthetic biology because of their well-known ability to produce secondary metabolites. However, the available constitutive promoters are rather limited in this genus. RESULTS In this work, constitutive promoters were selected from a pool of promoters whose downstream genes maintained constant expression profile...

2017
Ramzan Kh Umarov Victor V Solovyev

Accurate computational identification of promoters remains a challenge as these key DNA regulatory regions have variable structures composed of functional motifs that provide gene-specific initiation of transcription. In this paper we utilize Convolutional Neural Networks (CNN) to analyze sequence characteristics of prokaryotic and eukaryotic promoters and build their predictive models. We trai...

2015
Bingyin Peng Thomas C Williams Matthew Henry Lars K Nielsen Claudia E Vickers

BACKGROUND Predictable control of gene expression is necessary for the rational design and optimization of cell factories. In the yeast Saccharomyces cerevisiae, the promoter is one of the most important tools available for controlling gene expression. However, the complex expression patterns of yeast promoters have not been fully characterised and compared on different carbon sources (glucose,...

2011
Ionas Erb Erik van Nimwegen

The availability of sequence specificities for a substantial fraction of yeast's transcription factors and comparative genomic algorithms for binding site prediction has made it possible to comprehensively annotate transcription factor binding sites genome-wide. Here we use such a genome-wide annotation for comprehensively studying promoter architecture in yeast, focusing on the distribution of...

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