Traumatic brain injury (TBI) is a major worldwide healthcare problem. Despite promising outcomes from many preclinical studies, the failure of several clinical studies to identify effective therapeutic and pharmacological approaches for TBI suggests that methods to improve the translational potential of preclinical studies are highly desirable. Rodent models of TBI are increasingly in demand fo...

Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis. However, the factors that mediate this mechanism have yet to be completely elucidated. In this study, we isolated CD13+CD44+ sphere cells (SCs) derived from liver cancer tissues and SK-Hep-1 cells, which possessed cancer stem cell-like properties. Through cytokine array analysis, growth differen...

Many chemists have attempted syntheses of extended π-electron network molecules because of the widespread interest in the chemistry, physics and materials science of such molecules and their potential applications. In particular, extended phenacene molecules, consisting of coplanar fused benzene rings in a repeating W-shaped pattern have attracted much attention because field-effect transistors...

Direct georeferencing (DG) for orthoimage production based on collinearity equations has emerging as a standard photogrammetric operation. In this paper, the basic idea of DG is realized and refined with 19 self-calibration parameters for rectifying airborne pushbroom hyperspectral images collected using the intelligent spectral imaging system (ISIS) scanner. Two experimental ISIS images along ...

Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no approved therapies or vaccines, many promising candidates are undergoing clinical trials, and several have h...

Macrorhabdosis is a debilitating syndrome in budgerigars (Melopsittacus undulatus) due to the ascomycetous yeast Macrorhabdus ornithogaster. In the present study, occurrences of acute macrorhabdosis resulting in severe mortality in budgerigar fledglings and the effect of different treatment regimens for the control of the disease were investigated. The budgerigar (Melopsittacus undulates) flock...

Short-term energy load forecasting, such as hourly predictions for the next n (n ≥ 2) hours, will benefit from exploiting the relationships among the n estimated outputs. This paper treats such multisteps ahead regression task as a sequence labeling (regression) problem, and adopts a Continuous Conditional Random Fields (CCRF) strategy. This discriminative approach intuitively integrates two la...

Self-consistent mean-field models are a powerful tool in the investigation of nuclear structure and low-energy dynamics. They are based on effective energy-density functionals, often formulated in terms of effective density-dependent nucleon-nucleon interactions. The free parameters of the functional are adjusted to empirical data. A proper choice of these parameters requires a comprehensive se...

Triple negative breast cancer (TNBC) accounts for 15%-20% of all breast cancer, and is still defined as what it is not. Currently, TNBC is the only type of breast cancer for which there are no approved targeted therapies and maximum tolerated dose chemotherapy with taxanes and anthracycline-containing regimens is still the standard of care in both the neoadjuvant and adjuvant settings. In the l...

Multicellular three-dimensional (3D) spheroids represent an experimental model that is intermediate in its complexity between monolayer cultures and patients' tumor. In the present study, we characterize multicellular spheroids from papillary (PTC) and follicular (FTC) thyroid cancers and from the corresponding normal tissues. We show that these 3D structures well recapitulate the features of t...