نتایج جستجو برای: prolonged stress

تعداد نتایج: 521414  

Journal: :Circulation 2004
Ken-ichiro Okada Tetsuo Minamino Yoshitane Tsukamoto Yulin Liao Osamu Tsukamoto Seiji Takashima Akio Hirata Masashi Fujita Yoko Nagamachi Takeshi Nakatani Chikao Yutani Kentaro Ozawa Satoshi Ogawa Hitonobu Tomoike Masatsugu Hori Masafumi Kitakaze

BACKGROUND The endoplasmic reticulum (ER) is recognized as an organelle that participates in folding secretory and membrane proteins. The ER responds to stress by upregulating ER chaperones, but prolonged and/or excess ER stress leads to apoptosis. However, the potential role of ER stress in pathophysiological hearts remains unclear. METHODS AND RESULTS Mice were subjected to transverse aorti...

Journal: :Nature Human Behaviour 2021

The pandemic is causing prolonged stress to our social connections, with major adverse consequences individual and societal health. As a group-living, cooperative species, we need policies of communal care for more equitable, resilient future, argues Robin Nelson.

Journal: :Behavioural Processes 2016
Jared Edward Reser

Prolonged psychological stress and accompanying elevations in blood cortisol are known to induce hypometabolism and decreasing synaptic density in the hippocampus and the prefrontal cortex (PFC). This article evaluates and explores evidence supporting the hypothesis that these, and other, selective effects of prolonged stress constitute a neuroecological program that adaptively modifies behavio...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Roee Admon Michael T Treadway Linda Valeri Malavika Mehta Samuel Douglas Diego A Pizzagalli

The development of robust laboratory procedures for acute stress induction over the last decades has greatly advanced our understanding of stress responses in humans and their underlying neurobiological mechanisms. Nevertheless, attempts to uncover linear relationships among endocrine, neural, and affective responses to stress have generally yielded inconsistent results. Here, 79 healthy female...

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