Background/Aim: This study was designed to investigate the effect of IL-39 on T24 bladder cancer (BC) cell line survival and growth. Materials Methods: In order assess direct survival, proliferation, apoptosis BC cells, we utilized a clonogenic assay, proliferation caspase-3 activity kits. Potential proliferative apoptotic molecular mechanisms were evaluated by RT-PCR. Results: Treatment cells ...

background: iron is an essential trace element in cell proliferation. several investigations demonstrate that iron deprivation inhibits cell proliferation. however, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. objective: in this study, the effect of iron on the proliferation and telomerase activity of lymphocytes stimulated by phytohemagglutini...

objective: osteoporosis or silent disease is a major bone disorder in elderly women in current century. estrogen has an important role in osteogenesis and prevention of bone fractures. hormone replacement therapy (hrt) is usually accompanied by such effects as breast and ovary cancers. thus, there is an increasing demand for replacement with plant phytoestrogens. this study is focused on determ...

Objective(s):Degradation of sphingosine 1-phosphate (S1P), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. Since the tumor progression effects of S1P and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of S1P in tumor p...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

BACKGROUND This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. MATERIAL AND METHODS MiR-506 mimics, inhibitor, and negative control (NC) were transfected into MDA-MB-231 breast cancer cells. Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration...

Abstract Background Metabolic dysregulation is one of the hallmarks tumor cell proliferation. Evidence indicates potential role 5′adenosine monophosphate-activated protein kinase (AMPK) and B/Akt signaling pathway in regulating proliferation, survival, apoptosis. The present study explores effect metformin HCl combination α- β-asarone on proliferation HepG2 cells presence high glucose levels si...

objective: assessments of cell reactions such as motility, orientation and activation to the topography of the substratum will assist with the fabrication of a proper implantable scaffold for future tissue engineering applications.the current challenge is to analyze the orientation effect of elecrospun nanofibers of poly (ε-caprolactone) (pcl) on viability and proliferation of mouse embryonic s...

mtt assay is designed for spectrophotometric quantification of cell growth and viability without using the radiactive isotopes. the aim of this study is com¬parison of ltt and mtt as sensitive poliferation assays in immunodeficient pa¬tients. 20 immunodeficient and 20 healthy subjects were selected in this study. all of them had normal lymphocytes count, normal cd3 and negative dth reac¬tion to...