in this study, we have investigated the proliferative response of human dermal fibroblasts isolated from normal and psoriatic individuals to different cytokines. we found that il-1, tnf (α) and egf are stimulatory whereas ifn « and 1 both showed inhibitory activity on fibroblast proliferation. il-6 a more recently described cytokine, showed no detectable effects on cell proliferation. investiga...

objective: helicobacter pylori has a well-established role in the development of gastric cancer. in vitro studies reveal increased proliferation of the gastric mucosa in the presence of h. pylori infection. it has been also shown that production of some cytokines, such as interleukin-1 beta (il-1b) is increased in h. pylori infection. in addition, il-1b increases proliferation of gastric epithe...

Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

Stemness of cancer cells contains limitless self-renewal proliferation. For the purpose proliferation, secretome might exert its effects via paracrine signaling. Specific microRNAs enclosed in stem could regulate expression anti-proliferative APRO family proteins. The biological functions proteins seems to be quite intricate, however, which a key modulator microRNAs, then proliferation cells. I...

background: the cultured mesenchymal stem cells (msc) have been used in many clinical trials however, there are still some concerns about the cultural conditions. one concern is related to the use of fbs as a widely used xenogeneic supplement in the culture system. human platelet-rich plasma (hprp) is a candidate replacement for fbs. in this study, the effect of hprp on msc proliferation and os...

Flavonoids from Marchantia convoluta (MCF) were studied for their ability to inhibit the proliferation of 2.2.15 cells. All concentration of MCF inhibited the secretion of HBsAg and HBeAg in the cultured medium by 2.2.15 cells. Analysis of morphological changes of MCF-treated cells by phase-contrast microscopy revealed a possible mode of action for MCF: inhibition of proliferation of 2.2.15 cel...

dates fruit has been used as staple food in the middle east for thousands of years and various types of dates are found worldwide. dates and their constituents show various roles in diseases prevention and treatment through anti-oxidant, anti-inflammatory, anti-bacterial activity. in the present study we investigated the activity of aqueous and n-hexane extracts of phoenix dactylifera l. fruit ...