the primary immunodeficiency (pi) disorders are abnormalities in development and maturation of the immune system. individuals with pi disease may experience frequent infections, which limit their abilities to exhibit physical and psychological well-being secondary to their illness. in this survey we compared health-related quality of life of primary immune deficient patients with healthy childr...

The norm defined by Busemann’s inequality establishes a class of star body intersection body. This class of star body plays a key role in the solution of Busemann-Petty problem. In 2003, Giannapoulos [1] defined a norm for a new class of half-section. Based on this norm, we give a geometric generalization of Busemann-Petty problem, and get its answer as a result.

This paper deals with inequalities for the volume of a convex body and the volume of the projection body, the L-centroid body, and their polars. Examples are the Blaschke-Santaló inequality, the Petty and Zhang projection inequalities, the Busemann-Petty inequality. Other inequalities of the same type are still at the stage of conjectures. The use of special continuous movements of convex bodie...

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This paper analyses mechanisms underlying firm’s compliance with environmental regulations. By using a political economy approach through a Principal-Agent model, we examine how the dynamic of environmental compliance could affect governance infrastructures by shaping the structure of institutional incentives related to stakeholder’s behaviors in regulation process. Taking the case of deforesta...

The growing diversity of heritable skin diseases, a practical challenge to clinicians and dermato-nosologists alike, has nonetheless served as a rich source of insight into skin biology and disease mechanisms. I summarize below some key insights from the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome with prominent dermatologic features, constituti...

Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of ...