As duration of inflammatory bowel disease (IBD), in particular ulcerative colitis (UC), is a major risk factor for the development of colorectal cancer (CRC), it is rational to propose a screening colonoscopy when the risk starts to increase, i.e., after 8-10 years from the onset of disease. If low-grade dysplasia is detected, the 9-fold increased risk of developing CRC reported in the most rec...

Until recently, the elective surgical treatment of patients with ulcerative colitis has been either proctocolectomy with a permanent ileostomy or colectomy and ileorectal anastomosis (IRA). The former technique has many disadvantages, not least being the psychological readjustment necessary to face life with an incontinent orifice on the abdominal wall. IRA appears on face value to be more acce...

Most common hepatobiliary manifestation of inflammatory bowel disease (IBD) are primary sclerosing cholangitis (PSC) and autoimmune hepatitis, ranking them as the main cause of liver transplantation (LT) in IBD setting. Course of pre-existing IBD after LT differs depending on many transplant related factors. Potential risk factors related to IBD deterioration after LT are tacrolimus-based immun...

The aim of this study was to determine what factors are important for the achievement of perfect anal continence after restorative proctocolectomy. One hundred patients underwent paired studies of anorectal physiology before and one year after restorative proctocolectomy with pelvic ileal reservoir (11 S, 25 J, 64 W) with stapled ileoanal anastomosis, without mucosectomy. Fifty seven patients a...

BACKGROUND Familial adenomatous polyposis is a hereditary disease characterized by the presence of thousands of colonic adenomas, which, if untreated, invariably undergo malignant transformation. Because this disease manifests at a young age, the laparoscopic approach to perform surgery would be desirable due to its cosmetic benefits. We describe our experience with this procedure and review th...

Laparoscopic colon surgery has become a proved method for the resection of both benign and malignant disease. With the advance of technological innovations and surgical experience, more complex laparoscopic procedures including restorative proctocolectomy have become increasingly used in the treatment of ulcerative colitis with safe and feasible results. When these operations are realized in a ...

There is general agreement that malignant change in ulcerative colitis mostly occurs in those patients whose large intestine is totally involved and have a history of symptoms for more than 10 years. Having thus defined the population of colitics most at risk the problem remains of identifying the individual patient destined to get carcinoma. There is yet no evidence that all the population at ...

INTRODUCTION The Singapore Polyposis Registry (SPR) was established in 1989 at the Singapore General Hospital. This initiative was aimed at providing a central registry service to facilitate identification, surveillance and management of families and individuals at high risk of colorectal cancer. The aim of the present study was to provide a comprehensive review of all patients with familial ad...

There is general agreement that malignant change in ulcerative colitis mostly occurs in those patients whose large intestine is totally involved and have a history of symptoms for more than 10 years. Having thus defined the population of colitics most at risk the problem remains of identifying the individual patient destined to get carcinoma. There is yet no evidence that all the population at ...

The incidence of primary Crohn colitis is uncommon and surgical treatment has remained controversial, although most patients with Crohn colitis eventually require surgical intervention. This study aims to compare the operative outcomes of patients who underwent segmental versus either total colectomy or total proctocolectomy for Crohn colitis and to assess potential risk factors associated with...