نتایج جستجو برای: principal factor analysis pfa

تعداد نتایج: 3538350  

Journal: :European journal of medicinal chemistry 2016
Nyssa Drinkwater Natalie B Vinh Shailesh N Mistry Rebecca S Bamert Chiara Ruggeri John P Holleran Sasdekumar Loganathan Alessandro Paiardini Susan A Charman Andrew K Powell Vicky M Avery Sheena McGowan Peter J Scammells

Malaria remains a global health problem, and though international efforts for treatment and eradication have made some headway, the emergence of drug-resistant parasites threatens this progress. Antimalarial therapeutics acting via novel mechanisms are urgently required. Plasmodium falciparum M1 and M17 are neutral aminopeptidases which are essential for parasite growth and development. Previou...

2017
Jérémy Castéra Pierre Clément

This work analyses the answers to a questionnaire from 8,285 in-service and pre-service teachers from 23 countries, elaborated by the Biohead-Citizen research project, to investigate teachers’ conceptions related to the genetic determinism of human behaviour. A principal components analysis is used to assess the main trends in all the interviewed teachers’ conceptions. This illustrates that inn...

2004
Jim Rehg

In this project you will explore the use of Principle Component Analysis (PCA) and Probabilistic PCA (PPCA). PPCA is closely-related to factor analysis, which is described in chapter 14 of your text. Our application is face recognition, following on the work of Moghadden and Pentland. A minimum version of this project would involve reading chapter 14 and conducting a face recognition experiment...

1997
Peter Dayan Michael Revow

This paper describes two new methods for modelling the manifolds of digitised images of handwritten digits. The models allow a priori information about the structure of the manifolds to be combined with empirical data. Accurate modelling of the manifolds allows digits to be discriminated using the relative probability densities under the alternative models. One of the methods is grounded in pri...

2014
A. Peter

Relationships are the primary assets of an enterprise, thus many industries today seem to be migrating from transactional mindset to relational mindset in their dealings with customers. Due to highly competitive nature of hotel industry, ability to develop and maintain long-term relationships with customers has become strategic issue. This study is focused on the assessment of the effect of int...

Journal: :Circulation research 2015
Eric Van Belle Antoine Rauch André Vincentelli Emmanuelle Jeanpierre Paulette Legendre Francis Juthier Christopher Hurt Carlo Banfi Natacha Rousse Anne Godier Claudine Caron Ahmed Elkalioubie Delphine Corseaux Annabelle Dupont Christophe Zawadzki Cédric Delhaye Frédéric Mouquet Guillaume Schurtz Dominique Deplanque Giulia Chinetti Bart Staels Jenny Goudemand Brigitte Jude Peter J Lenting Sophie Susen

RATIONALE Percutaneous aortic valve procedures are a major breakthrough in the management of patients with aortic stenosis. Residual gradient and residual aortic regurgitation are major predictors of midterm and long-term outcome after percutaneous aortic valve procedures. We hypothesized that (1) induction/recovery of high molecular weight (HMW) multimers of von Willebrand factor defect could ...

Journal: :Journal of Systems and Software 2015
Lucas Gren Richard Torkar Robert Feldt

Agile development has now become a well-known approach to collaboration in professional work life. Both researchers and practitioners want validated tools to measure agility. This study sets out to validate an agile maturitymeasurementmodel with statistical tests and empirical data. First, a pretest was conducted as a case study including a survey and focus group. Second, the main study was con...

2015
Chiara Ruggeri Nyssa Drinkwater Komagal Kannan Sivaraman Rebecca S. Bamert Sheena McGowan Alessandro Paiardini Juan Carlos Pizarro

The Plasmodium falciparum PfA-M1 and PfA-M17 metalloaminopeptidases are validated drug targets for the discovery of antimalarial agents. In order to identify dual inhibitors of both proteins, we developed a hierarchical virtual screening approach, followed by in vitro evaluation of the highest scoring hits. Starting from the ZINC database of purchasable compounds, sequential 3D-pharmacophore an...

Journal: :Seminars in thrombosis and hemostasis 2008
Emmanuel J Favaloro

The PFA-100 (platelet function analyzer) is a relatively new tool for the investigation of primary hemostasis. This article reviews the history of the PFA-100 and details its clinical utility in several settings. The PFA-100 was first introduced to us in 1995 in an issue of Seminars in Thrombosis And Hemostasis, which included data from a field trial headed by Dr. Eberhard Mammen. Since that ti...

2002
Yutaka KANO Yusuke MIYAMOTO Shohei SHIMIZU

Similarities and distinctions have been pointed out between ICA and traditional multivariate methods such as factor analysis, principal component analysis and projection pursuit. In this paper, a new important connection between ICA and traditional factor analysis is made. The key of the connection is “factor rotation.”

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